DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PTPLTS
Uniprot ID:
O94910
Source protein:
Adhesion G protein-coupled receptor L1
Source gene:
ADGRL1
Class:
DEG_SCF_FBW7_1
Location:
419:424
E3 ligase:
FBXW7
DEGRON score:
0.578
ASA_SCORE:
89.55
COIL:
0.9367
CONS_SCORE:
0.3356
DSS_SCORE:
0.7183
HELIX:
0.0118
FCONS_SCORE:
0.9505
RIG_SCORE:
0.6512
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ADGRL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPLTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94910
Adhesion G protein-coupled receptor L1
DEG_SCF_FBW7_1
419:424
PTPLTS
FBXW7
0.578
More...
P51816
AF4/FMR2 family member 2
DEG_SCF_FBW7_1
369:374
PTPLTS
FBXW7
0.973
More...