DegronMD

Uniprot ID: P51816

Source protein: AF4/FMR2 family member 2

Source gene: AFF2

Class: DEG_SCF_FBW7_2

Location: 515:521

E3 ligase: FBXW7

DEGRON score: 0.9732

ASA_SCORE: 109.6714

COIL: 0.9773

CONS_SCORE: 0.3825

DSS_SCORE: 0.7834

HELIX: 0.0093

FCONS_SCORE: 0.7985

RIG_SCORE: 0.6023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E519D	TCGA-69-7979	LUAD	TCGA	VATPEPE	DEG_SCF_FBW7_2	0.5647
p.E519D	DO23874	LUAD	ICGC	VATPEPE	DEG_SCF_FBW7_2	0.5647
p.T505S	TCGA-75-6214	LUAD	TCGA	VATPEPE	DEG_SCF_FBW7_2	0.0556
p.T505S	DO24830	LUAD	ICGC	VATPEPE	DEG_SCF_FBW7_2	0.0556
p.P513H	TCGA-B0-5097	KIRC	TCGA	VATPEPE	DEG_SCF_FBW7_2	0.2778
p.P513H	DO19370	KIRC	ICGC	VATPEPE	DEG_SCF_FBW7_2	0.2778
p.R514H	TCGA-HT-7693	LGG	TCGA	VATPEPE	DEG_SCF_FBW7_2	0.3056
p.R514H	DO22191	LGG	ICGC	VATPEPE	DEG_SCF_FBW7_2	0.3056
p.Q529H	DO32893	PACA	ICGC	VATPEPE	DEG_SCF_FBW7_2	0.1111
p.T517N	SIDM00789	Colorectal Carcinoma	GDSC	VATPEPE	DEG_SCF_FBW7_2	0.8166
p.T517N	ACH-000997	Colon/Colorectal Cancer	CCLE	VATPEPE	DEG_SCF_FBW7_2	0.8166
p.T517N	HCT-15	large_intestine	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.8166
p.T525N	ACH-000872	Lung Cancer	CCLE	VATPEPE	DEG_SCF_FBW7_2	0.2222
p.G512D	SiHa	cervix	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.25
p.G512D	RERF-LC-MS	lung	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.25
p.G514D	RERF-LC-MS	lung	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.3056
p.G514D	SiHa	cervix	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.3056
p.R511H	TE-15	oesophagus	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.2222
p.P529T	IA-LM	lung	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.1111
p.M520I	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.7618
p.E519K	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.591
p.P524L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.25
p.P526L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.1944
p.E521K	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.7022
p.M518I	MCC13	skin	COSMIC	VATPEPE	DEG_SCF_FBW7_2	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51816	AF4/FMR2 family member 2	DEG_SCF_FBW7_2	515:521	VATPEPE	FBXW7	0.9732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons