DegronMD - P51826(AFF3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H236P	TCGA-05-4405	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7694
p.S724F	TCGA-33-4532	LUSC	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.2222
p.S724F	SIDM01772	Mesothelioma	GDSC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.2222
p.R846L	TCGA-56-7222	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.8428
p.A229T	TCGA-A5-A0G2	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.3056
p.A229T	TCGA-DX-A6YX	SARC	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.3056
p.A229T	DO220013	SARC	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.3056
p.A229T	DO41235	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.3056
p.E379D	TCGA-AP-A0LM	UCEC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1667
p.E379D	DO43306	UCEC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1667
p.A376V	TCGA-AX-A1C5	UCEC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833
p.Q719H	TCGA-B5-A1MX	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0833
p.D394N	TCGA-B5-A3FA	UCEC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.3056
p.K858R	TCGA-CV-5439	HNSC	TCGA	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1111
p.V721M	TCGA-DI-A1BU	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1389
p.V721M	DO42023	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1389
p.E851K	TCGA-DM-A28H	COAD	TCGA	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.3056
p.E851K	DO8906	COAD	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.3056
p.A736S	TCGA-EJ-A65B	PRAD	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation substituting flanking lysine	0.3333
p.A736S	DO49751	PRAD	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation substituting flanking lysine	0.3333
p.S380N	TCGA-EK-A2PM	CESC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1944
p.D400N	TCGA-EK-A2RC	CESC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.D400N	DO49945	CESC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.A228V	TCGA-EO-A22R	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.2778
p.A736V	TCGA-EY-A1GI	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation substituting flanking lysine	0.3333
p.A376T	TCGA-FD-A3N5	BLCA	TCGA	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833
p.C848R	TCGA-HC-7080	PRAD	TCGA	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.8301
p.C848R	DO36378	PRAD	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.8301
p.A723V	TCGA-IB-7651	PAAD	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.A723V	DO46657	PAAD	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.D730H	TCGA-S5-A6DX	BLCA	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7688
p.D730H	DO51903	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7688
p.S232N	TCGA-XK-AAIW	PRAD	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7069
p.S232N	DO51407	PRAD	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7069
p.A735T	DO44061	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.A735T	DO42568	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.D394V	DO50064	BRCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.3056
p.Q836H	DO230343	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.0556
p.R390C	DO227668	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.719
p.R390C	DO38723	STAD	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.719
p.R390C	DO42073	UCEC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.719
p.A233V	DO227978	COCA	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6936
p.A233V	DO232224	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6936
p.A233V	DO41235	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6936
p.S383N	DO229010	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.S383N	DO229013	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.S383N	DO229016	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.S383N	DO229003	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.S383N	DO229005	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.G384C	DO234350	ESAD	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.3056
p.E838D	DO14990	HNSC	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1111
p.N859S	DO229353	LAML	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.0833
p.A376E	DO228974	LICA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833
p.T385K	DO229031	LICA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7306
p.P719T	DO229035	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0833
p.E380D	DO52326	LIHC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1944
p.F742L	DO45299	LIRI	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0556
p.G837R	DO231145	LUSC	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.0833
p.P243L	DO222714	MELA	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.1944
p.E739K	DO28206	OV	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1389
p.D733H	DO219949	SARC	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.3056
p.R236K	DO37406	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6126
p.T232A	DO50119	STAD	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6028
p.T232A	ACH-000362	Leukemia	CCLE	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6028
p.T232A	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.6028
p.R844W	DO229268	THCA	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.2778
p.V397M	DO229275	THCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2222
p.P231L	DO231312	THCA	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7582
p.V723I	DO223282	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.R855M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1944
p.R855M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1944
p.R855M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1944
p.S389L	SIDM00545	Melanoma	GDSC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7667
p.S389L	Mewo	skin	COSMIC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7667
p.A737T	SIDM00188	Kidney Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.A737T	SIDM01711	Non-Cancerous	GDSC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.A737T	SIDM00918	Ovarian Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.A737T	SIDM00368	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.T220I	SIDM00516	Melanoma	GDSC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.0556
p.T220I	MZ7-mel	skin	COSMIC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.0556
p.E735D	SIDM00989	Bladder Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.E735D	BFTC-905	urinary tract	COSMIC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.S244F	SIDM01159	Other Sarcomas	GDSC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.1667
p.S244F	SW872	soft tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.1667
p.C848Y	SIDM01409	Bladder Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.7087
p.E740K	ACH-000247	Gastric Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.E740K	ACH-000805	Skin Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.E740K	OCUM-1	stomach	COSMIC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.E740K	COLO-679	skin	COSMIC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.A735S	ACH-000481	Lung Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.A735S	NCI-H2170	lung	COSMIC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.S393A	ACH-000786	Lymphoma	CCLE	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7588
p.E247V	ACH-000870	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.0833
p.A244S	ACH-000871	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.1667
p.A244S	NCI-H510A	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation rewiring degron network	0.1667
p.L389P	ACH-000989	Colon/Colorectal Cancer	CCLE	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7582
p.L389P	SNU-175	large intestine	COSMIC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7582
p.T730N	ACH-002394	Colon/Colorectal Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7055
p.T730N	GEO	large intestine	COSMIC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7055
p.S726F	Sarc9371	bone	COSMIC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFF3

UniProt ID: P51826

Entrez ID: 3899

Protein name: AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFF3 in