DegronMD - P51826(AFF3)

FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.

GO - Biological processes (BP): embryonic hindlimb morphogenesis [GO:0035116]; regulation of gene expression [GO:0010468]; response to tumor necrosis factor [GO:0034612]

GO - Molecular function (MF): DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]

GO - Cellular component (CC): cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; super elongation complex [GO:0032783]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R846L	TCGA-56-7222	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.8428
p.C848R	TCGA-HC-7080	PRAD	TCGA	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.8301
p.C848R	DO36378	PRAD	ICGC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.8301
p.H236P	TCGA-05-4405	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7694
p.D730H	TCGA-S5-A6DX	BLCA	TCGA	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7688
p.D730H	DO51903	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7688
p.S389L	SIDM00545	Melanoma	GDSC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7667
p.S389L	Mewo	skin	COSMIC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7667
p.S393A	ACH-000786	Lymphoma	CCLE	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7588
p.P231L	DO231312	THCA	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7582
p.L389P	ACH-000989	Colon/Colorectal Cancer	CCLE	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7582
p.L389P	SNU-175	large intestine	COSMIC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7582
p.T385K	DO229031	LICA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7306
p.R390C	DO227668	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.719
p.R390C	DO38723	STAD	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.719
p.R390C	DO42073	UCEC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.719
p.C848Y	SIDM01409	Bladder Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.7087
p.S232N	TCGA-XK-AAIW	PRAD	TCGA	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7069
p.S232N	DO51407	PRAD	ICGC	KPTAYVRPM	DEG_SIAH_1	230:238	Mutation altering degron motif	0.7069
p.T730N	ACH-002394	Colon/Colorectal Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7055

Showing 1 to 20 of 100 entries

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Kaplan plot for AFF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AFF3

UniProt ID: P51826

Entrez ID: 3899

Protein name: AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AFF3 in