DegronMD

Uniprot ID: P51826

Source protein: AF4/FMR2 family member 3

Source gene: AFF3

Class: DEG_SPOP_SBC_1

Location: 728:732

E3 ligase: SPOP

DEGRON score: 0.5704

ASA_SCORE: 94.68

COIL: 0.7706

CONS_SCORE: 0.3622

DSS_SCORE: 0.4846

HELIX: 0.2122

FCONS_SCORE: 0.87

RIG_SCORE: 0.7294

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S724F	TCGA-33-4532	LUSC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.2222
p.S724F	SIDM01772	Mesothelioma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.2222
p.Q719H	TCGA-B5-A1MX	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.0833
p.V721M	TCGA-DI-A1BU	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1389
p.V721M	DO42023	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.A736S	TCGA-EJ-A65B	PRAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.3333
p.A736S	DO49751	PRAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.3333
p.A736V	TCGA-EY-A1GI	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.3333
p.A723V	TCGA-IB-7651	PAAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1944
p.A723V	DO46657	PAAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.D730H	TCGA-S5-A6DX	BLCA	TCGA	ARTTS	DEG_SPOP_SBC_1	0.7688
p.D730H	DO51903	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.7688
p.A735T	DO44061	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.25
p.A735T	DO42568	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.25
p.P719T	DO229035	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.0833
p.F742L	DO45299	LIRI	ICGC	ARTTS	DEG_SPOP_SBC_1	0.0556
p.E739K	DO28206	OV	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.D733H	DO219949	SARC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.3056
p.V723I	DO223282	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.A737T	SIDM00188	Kidney Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.A737T	SIDM01711	Non-Cancerous	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.A737T	SIDM00918	Ovarian Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.A737T	SIDM00368	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.E735D	SIDM00989	Bladder Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.25
p.E735D	BFTC-905	urinary_tract	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.25
p.E740K	ACH-000247	Gastric Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.1111
p.E740K	ACH-000805	Skin Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.1111
p.E740K	OCUM-1	stomach	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.E740K	COLO-679	skin	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A735S	ACH-000481	Lung Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.25
p.A735S	NCI-H2170	lung	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.25
p.T730N	ACH-002394	Colon/Colorectal Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.7055
p.T730N	GEO	large_intestine	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.7055
p.S726F	Sarc9371	bone	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	2:6	ARTTS	SPOP	0.9984	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	728:732	ARTTS	SPOP	0.5704	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2282:2286	ARTTS	SPOP	0.9001	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SPOP_SBC_1	271:275	ARTTS	SPOP	0.9868	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SPOP_SBC_1	456:460	ARTTS	SPOP	0.602	More...
Q86VZ1	P2Y purinoceptor 8	DEG_SPOP_SBC_1	328:332	ARTTS	SPOP	0.87	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARTTS

Degron related mutations and impact score

Drug responses associated with AFF3 mutations

All proteins holding degron of ARTTS