DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 2282:2286

E3 ligase: SPOP

DEGRON score: 0.9001

ASA_SCORE: 97.6

COIL: 0.8458

CONS_SCORE: 0.4777

DSS_SCORE: 0.6932

HELIX: 0.0316

FCONS_SCORE: 1.186

RIG_SCORE: 0.6588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2288S	SIDM00393	Gastric Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.2778
p.R2291I	SIDM01002	Breast Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.T2290A	SIDM00761	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	2:6	ARTTS	SPOP	0.9984	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	728:732	ARTTS	SPOP	0.5704	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2282:2286	ARTTS	SPOP	0.9001	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SPOP_SBC_1	271:275	ARTTS	SPOP	0.9868	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SPOP_SBC_1	456:460	ARTTS	SPOP	0.602	More...
Q86VZ1	P2Y purinoceptor 8	DEG_SPOP_SBC_1	328:332	ARTTS	SPOP	0.87	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons