DegronMD

Uniprot ID: Q9UHR4

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Source gene: BAIAP2L1

Class: DEG_SPOP_SBC_1

Location: 456:460

E3 ligase: SPOP

DEGRON score: 0.602

ASA_SCORE: 99.76

COIL: 0.901

CONS_SCORE: 0.4125

DSS_SCORE: 0.586

HELIX: 0.0948

FCONS_SCORE: 0.93

RIG_SCORE: 0.6731

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G446V	TCGA-50-6594	LUAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.0556
p.G446V	DO24275	LUAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.0556
p.A466V	TCGA-FI-A2D5	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1667
p.A466V	DO41331	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.S460T	DO229003	COCA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	DO229505	LAML	ICGC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00578	Neuroblastoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00434	Plasma Cell Myeloma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00353	Other Sarcomas	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00435	Acute Myeloid Leukemia	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00600	Thyroid Gland Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00370	T-Lymphoblastic Leukemia	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00555	Glioblastoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00463	T-Lymphoblastic Leukemia	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00394	Cervical Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00060	Ovarian Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00287	B-Lymphoblastic Leukemia	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01045	Endometrial Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00487	Colorectal Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00505	Pancreatic Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00498	Colorectal Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00410	Other Blood Cancers	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00280	Gastric Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00807	Bladder Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00655	Other Solid Cancers	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01217	Other Blood Cancers	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00986	Head and Neck Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00503	Gastric Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01018	Hodgkin's Lymphoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00575	Glioma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00192	Colorectal Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01449	Pancreatic Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01393	Gastric Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01578	Bladder Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01336	Glioblastoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01472	Hepatocellular Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01779	Gastric Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01435	Hepatocellular Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01446	Glioblastoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00164	Biliary Tract Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM00500	Colorectal Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01587	Bladder Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01574	Plasma Cell Myeloma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.S460T	SIDM01343	Gastric Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.6005
p.A449D	DO228976	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.A456D	DO229009	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.7793
p.D450N	DO231040	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.D450V	DO233298	NACA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.A448T	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM01649	Non-Cancerous	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00632	Non-Cancerous	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM01129	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00263	Ewing's Sarcoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00934	Pancreatic Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM01081	Oral Cavity Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00143	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00817	Kidney Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00342	T-Lymphoblastic Leukemia	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM01050	Biliary Tract Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00736	Non-Cancerous	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM01170	Ovarian Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00519	Mesothelioma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00184	Melanoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM00490	Glioma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A448T	SIDM01772	Mesothelioma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1111
p.A449T	SIDM00118	Colorectal Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.A449T	ACH-001081	Colon/Colorectal Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.1389
p.A449T	HCC2998	large_intestine	COSMIC	ARTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	2:6	ARTTS	SPOP	0.9984	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	728:732	ARTTS	SPOP	0.5704	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2282:2286	ARTTS	SPOP	0.9001	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SPOP_SBC_1	271:275	ARTTS	SPOP	0.9868	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SPOP_SBC_1	456:460	ARTTS	SPOP	0.602	More...
Q86VZ1	P2Y purinoceptor 8	DEG_SPOP_SBC_1	328:332	ARTTS	SPOP	0.87	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARTTS

Degron related mutations and impact score

Drug responses associated with BAIAP2L1 mutations

All proteins holding degron of ARTTS