DegronMD - Q86VZ1(P2RY8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A328T	TCGA-02-0055	GBM	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7139
p.A328T	DO10873	GBM	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7139
p.T331M	TCGA-06-2564	GBM	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.8534
p.T331M	TCGA-G9-6354	PRAD	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.8534
p.T331M	DO13378	GBM	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.8534
p.T331M	DO48595	PRAD	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.8534
p.A339V	TCGA-62-8395	LUAD	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.A339V	DO45368	LUAD	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.S327Y	TCGA-77-7141	LUSC	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.75
p.S327Y	DO26450	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.75
p.T320S	TCGA-86-7701	LUAD	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.5556
p.T320S	DO24441	LUAD	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.5556
p.R321G	TCGA-98-A538	LUSC	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R321G	DO219177	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.V333L	TCGA-AJ-A3EM	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.3056
p.V333L	DO41680	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.3056
p.E323K	TCGA-B7-A5TJ	STAD	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1944
p.E323K	DO222329	STAD	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1944
p.R321H	TCGA-BS-A0UV	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R321H	DO42793	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R329K	TCGA-EB-A431	SKCM	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.6126
p.R329K	DO37671	SKCM	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.6126
p.R321C	TCGA-EY-A2OP	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R321C	DO48437	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R321C	DO42560	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.S335F	TCGA-GN-A4U3	SKCM	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.6944
p.S335F	DO219484	SKCM	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.6944
p.R322C	TCGA-KB-A93H	STAD	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R322C	DO51747	STAD	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.S327C	TCGA-SY-A9G5	BLCA	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.75
p.S327C	DO51906	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation blocking phosphorylation signal	0.75
p.A328S	TCGA-VQ-A924	STAD	TCGA	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7588
p.A328S	DO51795	STAD	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7588
p.A337D	DO229024	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1944
p.R322S	DO229032	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R334H	DO229207	LMS	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.2778
p.R322L	DO230530	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R322H	DO41056	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1667
p.R321S	SIDM01118	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R321S	ACH-002175	Lung Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation rewiring degron network	0.1389
p.R329M	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7521
p.R329M	ACH-000596	Lung Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	328:332	Mutation altering degron motif	0.7521

DegronMD: protein-targeted degradation, mutation and drug response to degrons

P2RY8

UniProt ID: Q86VZ1

Entrez ID: 286530

Protein name: P2Y purinoceptor 8 (P2Y8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for P2RY8 in