DegronMD

Uniprot ID: Q86VZ1

Source protein: P2Y purinoceptor 8

Source gene: P2RY8

Class: DEG_SPOP_SBC_1

Location: 328:332

E3 ligase: SPOP

DEGRON score: 0.87

ASA_SCORE: 114.36

COIL: 0.914

CONS_SCORE: 0.7025

DSS_SCORE: 0.558

HELIX: 0.0552

FCONS_SCORE: 1.3935

RIG_SCORE: 0.6986

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A328T	TCGA-02-0055	GBM	TCGA	ARTTS	DEG_SPOP_SBC_1	0.7139
p.A328T	DO10873	GBM	ICGC	ARTTS	DEG_SPOP_SBC_1	0.7139
p.T331M	TCGA-06-2564	GBM	TCGA	ARTTS	DEG_SPOP_SBC_1	0.8534
p.T331M	TCGA-G9-6354	PRAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.8534
p.T331M	DO13378	GBM	ICGC	ARTTS	DEG_SPOP_SBC_1	0.8534
p.T331M	DO48595	PRAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.8534
p.A339V	TCGA-62-8395	LUAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1389
p.A339V	DO45368	LUAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.S327Y	TCGA-77-7141	LUSC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.75
p.S327Y	DO26450	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.75
p.T320S	TCGA-86-7701	LUAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.5556
p.T320S	DO24441	LUAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.5556
p.R321G	TCGA-98-A538	LUSC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R321G	DO219177	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.V333L	TCGA-AJ-A3EM	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.3056
p.V333L	DO41680	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.3056
p.E323K	TCGA-B7-A5TJ	STAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1944
p.E323K	DO222329	STAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.R321H	TCGA-BS-A0UV	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R321H	DO42793	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R329K	TCGA-EB-A431	SKCM	TCGA	ARTTS	DEG_SPOP_SBC_1	0.6126
p.R329K	DO37671	SKCM	ICGC	ARTTS	DEG_SPOP_SBC_1	0.6126
p.R321C	TCGA-EY-A2OP	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R321C	DO48437	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R321C	DO42560	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.S335F	TCGA-GN-A4U3	SKCM	TCGA	ARTTS	DEG_SPOP_SBC_1	0.6944
p.S335F	DO219484	SKCM	ICGC	ARTTS	DEG_SPOP_SBC_1	0.6944
p.R322C	TCGA-KB-A93H	STAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.1667
p.R322C	DO51747	STAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.S327C	TCGA-SY-A9G5	BLCA	TCGA	ARTTS	DEG_SPOP_SBC_1	0.75
p.S327C	DO51906	BLCA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.75
p.A328S	TCGA-VQ-A924	STAD	TCGA	ARTTS	DEG_SPOP_SBC_1	0.7588
p.A328S	DO51795	STAD	ICGC	ARTTS	DEG_SPOP_SBC_1	0.7588
p.A337D	DO229024	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1944
p.R322S	DO229032	LICA	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.R334H	DO229207	LMS	ICGC	ARTTS	DEG_SPOP_SBC_1	0.2778
p.R322L	DO230530	LUSC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.R322H	DO41056	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	0.1667
p.R321S	SIDM01118	Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R321S	ACH-002175	Lung Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.1389
p.R329M	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	0.7521
p.R329M	ACH-000596	Lung Cancer	CCLE	ARTTS	DEG_SPOP_SBC_1	0.7521

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	2:6	ARTTS	SPOP	0.9984	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	728:732	ARTTS	SPOP	0.5704	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2282:2286	ARTTS	SPOP	0.9001	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SPOP_SBC_1	271:275	ARTTS	SPOP	0.9868	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SPOP_SBC_1	456:460	ARTTS	SPOP	0.602	More...
Q86VZ1	P2Y purinoceptor 8	DEG_SPOP_SBC_1	328:332	ARTTS	SPOP	0.87	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARTTS

Degron related mutations and impact score

Drug responses associated with P2RY8 mutations

All proteins holding degron of ARTTS