DegronMD - Q96JM3(CHAMP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L550P	TCGA-2Z-A9JO	KIRP	TCGA	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.7582
p.L550P	DO219681	KIRP	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.7582
p.I663V	TCGA-34-2596	LUSC	TCGA	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.25
p.I663V	DO26508	LUSC	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.25
p.G579S	TCGA-AF-3914	READ	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.1111
p.G579S	DO36475	READ	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.1111
p.A529V	TCGA-AH-6643	READ	TCGA	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation altering degron motif	0.5825
p.A529V	DO36591	READ	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation altering degron motif	0.5825
p.S366Y	TCGA-AJ-A5DW	UCEC	TCGA	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation altering degron motif	0.712
p.S366Y	DO50075	UCEC	ICGC	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation altering degron motif	0.712
p.E577Q	TCGA-AO-A12D	BRCA	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.1667
p.E577Q	DO4707	BRCA	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.1667
p.R268W	TCGA-AP-A0LM	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.R268W	DO43306	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.L568I	TCGA-AX-A2HC	UCEC	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.6063
p.L568I	DO41572	UCEC	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.6063
p.R555W	TCGA-AX-A2HD	UCEC	TCGA	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation rewiring degron network	0.2778
p.R555W	TCGA-AX-A2HD	UCEC	TCGA	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.3056
p.R555W	TCGA-AX-A2HD	UCEC	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.0556
p.R555W	DO42608	UCEC	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation rewiring degron network	0.2778
p.R555W	DO42608	UCEC	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.3056
p.R555W	DO42608	UCEC	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.0556
p.R546C	TCGA-B6-A1KF	BRCA	TCGA	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation rewiring degron network	0.3056
p.R546C	TCGA-B6-A1KF	BRCA	TCGA	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.0556
p.R546C	DO1604	BRCA	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation rewiring degron network	0.3056
p.R546C	DO1604	BRCA	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.0556
p.P352S	TCGA-D3-A51G	SKCM	TCGA	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.0833
p.P352S	DO47700	SKCM	ICGC	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.0833
p.P561S	TCGA-DA-A960	SKCM	TCGA	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.5641
p.P561S	DO219482	SKCM	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.5641
p.P561L	TCGA-DA-A960	SKCM	TCGA	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.6471
p.P561L	DO219482	SKCM	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.6471
p.R548G	TCGA-DX-A48V	SARC	TCGA	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.6457
p.R548G	DO219991	SARC	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.6457
p.P532S	TCGA-EE-A3AF	SKCM	TCGA	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation altering degron motif	0.5641
p.P532S	DO37911	SKCM	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation altering degron motif	0.5641
p.P356S	TCGA-EE-A3JH	SKCM	TCGA	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.1944
p.P356S	DO47595	SKCM	ICGC	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.1944
p.P356L	TCGA-EE-A3JH	SKCM	TCGA	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.1944
p.P356L	DO47595	SKCM	ICGC	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.1944
p.D522N	TCGA-EO-A22S	UCEC	TCGA	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation rewiring degron network	0.1944
p.D522N	DO41590	UCEC	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation rewiring degron network	0.1944
p.G579D	TCGA-EO-A22U	UCEC	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.1111
p.G579D	DO43755	UCEC	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.1111
p.R268Q	TCGA-FI-A2F4	UCEC	TCGA	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.R268Q	DO43434	UCEC	ICGC	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.R268Q	SIDM02049	Pancreatic Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.D664V	TCGA-HU-A4GH	STAD	TCGA	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.2778
p.D664V	DO47743	STAD	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.2778
p.D672G	TCGA-VQ-A91D	STAD	TCGA	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.2778
p.D672G	DO51783	STAD	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.2778
p.L568V	TCGA-YL-A9WK	PRAD	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.L568V	DO51443	PRAD	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.L568V	SIDM00018	Acute Myeloid Leukemia	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.L568V	SIDM00540	Oral Cavity Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.L568V	SIDM00381	Cervical Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.L568V	SIDM01577	Plasma Cell Myeloma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.L568V	SIDM01472	Hepatocellular Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.5654
p.P517R	DO222857	BTCA	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation rewiring degron network	0.0556
p.T523I	DO230342	COCA	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	527:533	Mutation rewiring degron network	0.2222
p.E175G	DO222737	COCA	ICGC	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation rewiring degron network	0.2778
p.T169A	DO233620	GACA	ICGC	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation altering degron motif	0.825
p.E677D	DO228976	LICA	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.1389
p.V660L	DO229019	LICA	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.1667
p.E175D	DO229027	LICA	ICGC	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation rewiring degron network	0.2778
p.R548H	DO50970	LICA	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.7133
p.R546P	DO230937	LUSC	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation rewiring degron network	0.3056
p.R546P	DO230937	LUSC	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.0556
p.R546P	DO224619	LUSC	ICGC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation rewiring degron network	0.3056
p.R546P	DO224619	LUSC	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.0556
p.R680K	DO231179	LUSC	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.0556
p.E668A	DO228349	MALY	ICGC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation altering degron motif	0.7701
p.E668A	SIDM00656	Burkitt's Lymphoma	GDSC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation altering degron motif	0.7701
p.E668A	SIDM00641	Burkitt's Lymphoma	GDSC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation altering degron motif	0.7701
p.E668A	ACH-000944	Lymphoma	CCLE	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation altering degron motif	0.7701
p.E668A	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation altering degron motif	0.7701
p.P564S	DO220873	MELA	ICGC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation rewiring degron network	0.2778
p.P564S	DO220873	MELA	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation rewiring degron network	0.3056
p.K547N	SIDM02039	Colorectal Carcinoma	GDSC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.6918
p.M671I	SIDM00845	Burkitt's Lymphoma	GDSC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.3056
p.M671I	SIDM00254	Neuroblastoma	GDSC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.3056
p.F560S	SIDM01174	Cervical Carcinoma	GDSC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.7982
p.F560S	SW756	cervix	COSMIC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.7982
p.R272W	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7523
p.R272W	NCI-H1563	lung	COSMIC	ARTTS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.7523
p.P174S	SIDM01081	Oral Cavity Carcinoma	GDSC	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation rewiring degron network	0.3056
p.P174S	SIDM00814	Other Solid Cancers	GDSC	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation rewiring degron network	0.3056
p.R548C	SIDM00217	Colorectal Carcinoma	GDSC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.719
p.R548C	ACH-000999	Colon/Colorectal Cancer	CCLE	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.719
p.R548C	SNU-1040	large intestine	COSMIC	KRALFPE	LIG_APCC_ABBAyCdc20_2	547:553	Mutation altering degron motif	0.719
p.A558T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.6028
p.A558T	ACH-001127	Leukemia	CCLE	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.6028
p.A558T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KHALFPE	LIG_APCC_ABBAyCdc20_2	556:562	Mutation altering degron motif	0.6028
p.S376L	SIDM01518	Oral Cavity Carcinoma	GDSC	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation blocking phosphorylation signal	0.5
p.S570L	SIDM01587	Bladder Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.7667
p.S570L	ACH-000753	Bladder Cancer	CCLE	KSALFSE	LIG_APCC_ABBAyCdc20_2	565:571	Mutation altering degron motif	0.7667
p.A180V	SIDM01588	Endometrial Carcinoma	GDSC	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation rewiring degron network	0.1389
p.A180V	ACH-000993	Endometrial/Uterine Cancer	CCLE	LQTPLPS	DEG_SCF_FBW7_1	167:173	Mutation rewiring degron network	0.1389
p.I351V	ACH-002669	Colon/Colorectal Cancer	CCLE	PTPSVS	DEG_SCF_FBW7_1	361:366	Mutation rewiring degron network	0.0556
p.T674A	NCI-H1975	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	666:670	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHAMP1

UniProt ID: Q96JM3

Entrez ID: 283489

Protein name: Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHAMP1 in