DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KHALFPE
Uniprot ID:
Q96JM3
Source protein:
Chromosome alignment-maintaining phosphoprotein 1
Source gene:
CHAMP1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
556:562
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.996
ASA_SCORE:
104.6143
COIL:
0.9329
CONS_SCORE:
0.6646
DSS_SCORE:
0.4599
HELIX:
0.0381
FCONS_SCORE:
0.8938
RIG_SCORE:
0.7225
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R555W
TCGA-AX-A2HD
UCEC
TCGA
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.3056
p.R555W
DO42608
UCEC
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.3056
p.R546C
TCGA-B6-A1KF
BRCA
TCGA
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.0556
p.R546C
DO1604
BRCA
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.0556
p.P561S
TCGA-DA-A960
SKCM
TCGA
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.5641
p.P561S
DO219482
SKCM
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.5641
p.P561L
TCGA-DA-A960
SKCM
TCGA
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.6471
p.P561L
DO219482
SKCM
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.6471
p.R546P
DO230937
LUSC
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.0556
p.R546P
DO224619
LUSC
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.0556
p.P564S
DO220873
MELA
ICGC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.2778
p.F560S
SIDM01174
Cervical Carcinoma
GDSC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.7982
p.F560S
SW756
cervix
COSMIC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.7982
p.A558T
SIDM00145
T-Lymphoblastic Leukemia
GDSC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.6028
p.A558T
ACH-001127
Leukemia
CCLE
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.6028
p.A558T
MOLT-4
haematopoietic_and_lymphoid_tissue
COSMIC
KHALFPE
LIG_APCC_ABBAyCdc20_2
0.6028
Drug responses associated with CHAMP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KHALFPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JM3
Chromosome alignment-maintaining phosphoprotein 1
LIG_APCC_ABBAyCdc20_2
556:562
KHALFPE
APC,CDC20,FZR1
0.996
More...