DegronMD

Uniprot ID: Q96JM3

Source protein: Chromosome alignment-maintaining phosphoprotein 1

Source gene: CHAMP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 527:533

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 103.2

COIL: 0.9577

CONS_SCORE: 0.6576

DSS_SCORE: 0.675

HELIX: 0.0196

FCONS_SCORE: 1.1424

RIG_SCORE: 0.6664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A529V	TCGA-AH-6643	READ	TCGA	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.5825
p.A529V	DO36591	READ	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.5825
p.P532S	TCGA-EE-A3AF	SKCM	TCGA	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.P532S	DO37911	SKCM	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.D522N	TCGA-EO-A22S	UCEC	TCGA	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D522N	DO41590	UCEC	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P517R	DO222857	BTCA	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T523I	DO230342	COCA	ICGC	KPALFPE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	LIG_APCC_ABBAyCdc20_2	527:533	KPALFPE	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons