DegronMD

Uniprot ID: Q96JM3

Source protein: Chromosome alignment-maintaining phosphoprotein 1

Source gene: CHAMP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 565:571

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9978

ASA_SCORE: 94.8143

COIL: 0.8584

CONS_SCORE: 0.6946

DSS_SCORE: 0.3703

HELIX: 0.128

FCONS_SCORE: 1.1301

RIG_SCORE: 0.7254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G579S	TCGA-AF-3914	READ	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G579S	DO36475	READ	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E577Q	TCGA-AO-A12D	BRCA	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E577Q	DO4707	BRCA	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L568I	TCGA-AX-A2HC	UCEC	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.6063
p.L568I	DO41572	UCEC	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.6063
p.R555W	TCGA-AX-A2HD	UCEC	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R555W	DO42608	UCEC	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G579D	TCGA-EO-A22U	UCEC	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G579D	DO43755	UCEC	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L568V	TCGA-YL-A9WK	PRAD	TCGA	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L568V	DO51443	PRAD	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L568V	SIDM00018	Acute Myeloid Leukemia	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L568V	SIDM00540	Oral Cavity Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L568V	SIDM00381	Cervical Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L568V	SIDM01577	Plasma Cell Myeloma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L568V	SIDM01472	Hepatocellular Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.5654
p.P564S	DO220873	MELA	ICGC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S570L	SIDM01587	Bladder Carcinoma	GDSC	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.7667
p.S570L	ACH-000753	Bladder Cancer	CCLE	KSALFSE	LIG_APCC_ABBAyCdc20_2	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	LIG_APCC_ABBAyCdc20_2	565:571	KSALFSE	APC,CDC20,FZR1	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons