DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KRALFPE
Uniprot ID:
Q96JM3
Source protein:
Chromosome alignment-maintaining phosphoprotein 1
Source gene:
CHAMP1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
547:553
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9979
ASA_SCORE:
113.8857
COIL:
0.9367
CONS_SCORE:
0.8464
DSS_SCORE:
0.5889
HELIX:
0.0513
FCONS_SCORE:
1.2776
RIG_SCORE:
0.6832
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L550P
TCGA-2Z-A9JO
KIRP
TCGA
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.7582
p.L550P
DO219681
KIRP
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.7582
p.R555W
TCGA-AX-A2HD
UCEC
TCGA
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.2778
p.R555W
DO42608
UCEC
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.2778
p.R546C
TCGA-B6-A1KF
BRCA
TCGA
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.3056
p.R546C
DO1604
BRCA
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.3056
p.R548G
TCGA-DX-A48V
SARC
TCGA
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.6457
p.R548G
DO219991
SARC
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.6457
p.R548H
DO50970
LICA
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.7133
p.R546P
DO230937
LUSC
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.3056
p.R546P
DO224619
LUSC
ICGC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.3056
p.K547N
SIDM02039
Colorectal Carcinoma
GDSC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.6918
p.R548C
SIDM00217
Colorectal Carcinoma
GDSC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.719
p.R548C
ACH-000999
Colon/Colorectal Cancer
CCLE
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.719
p.R548C
SNU-1040
large_intestine
COSMIC
KRALFPE
LIG_APCC_ABBAyCdc20_2
0.719
Drug responses associated with CHAMP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KRALFPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JM3
Chromosome alignment-maintaining phosphoprotein 1
LIG_APCC_ABBAyCdc20_2
547:553
KRALFPE
APC,CDC20,FZR1
0.9979
More...