DegronMD

Uniprot ID: Q96JM3

Source protein: Chromosome alignment-maintaining phosphoprotein 1

Source gene: CHAMP1

Class: DEG_SCF_FBW7_1

Location: 361:366

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 83.6

COIL: 0.9623

CONS_SCORE: 0.5779

DSS_SCORE: 0.4579

HELIX: 0.016

FCONS_SCORE: 0.8861

RIG_SCORE: 0.629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S366Y	TCGA-AJ-A5DW	UCEC	TCGA	PTPSVS	DEG_SCF_FBW7_1	0.712
p.S366Y	DO50075	UCEC	ICGC	PTPSVS	DEG_SCF_FBW7_1	0.712
p.P352S	TCGA-D3-A51G	SKCM	TCGA	PTPSVS	DEG_SCF_FBW7_1	0.0833
p.P352S	DO47700	SKCM	ICGC	PTPSVS	DEG_SCF_FBW7_1	0.0833
p.P356S	TCGA-EE-A3JH	SKCM	TCGA	PTPSVS	DEG_SCF_FBW7_1	0.1944
p.P356S	DO47595	SKCM	ICGC	PTPSVS	DEG_SCF_FBW7_1	0.1944
p.P356L	TCGA-EE-A3JH	SKCM	TCGA	PTPSVS	DEG_SCF_FBW7_1	0.1944
p.P356L	DO47595	SKCM	ICGC	PTPSVS	DEG_SCF_FBW7_1	0.1944
p.S376L	SIDM01518	Oral Cavity Carcinoma	GDSC	PTPSVS	DEG_SCF_FBW7_1	0.5
p.I351V	ACH-002669	Colon/Colorectal Cancer	CCLE	PTPSVS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SCF_FBW7_1	361:366	PTPSVS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons