DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ARTTS
Uniprot ID:
Q96JM3
Source protein:
Chromosome alignment-maintaining phosphoprotein 1
Source gene:
CHAMP1
Class:
DEG_SPOP_SBC_1
Location:
271:275
E3 ligase:
SPOP
DEGRON score:
0.9868
ASA_SCORE:
97.58
COIL:
0.962
CONS_SCORE:
0.6475
DSS_SCORE:
0.7377
HELIX:
0.0154
FCONS_SCORE:
0.7935
RIG_SCORE:
0.5169
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R268W
TCGA-AP-A0LM
UCEC
TCGA
ARTTS
DEG_SPOP_SBC_1
0.25
p.R268W
DO43306
UCEC
ICGC
ARTTS
DEG_SPOP_SBC_1
0.25
p.R268Q
TCGA-FI-A2F4
UCEC
TCGA
ARTTS
DEG_SPOP_SBC_1
0.25
p.R268Q
DO43434
UCEC
ICGC
ARTTS
DEG_SPOP_SBC_1
0.25
p.R268Q
SIDM02049
Pancreatic Carcinoma
GDSC
ARTTS
DEG_SPOP_SBC_1
0.25
p.R272W
SIDM00751
Non-Small Cell Lung Carcinoma
GDSC
ARTTS
DEG_SPOP_SBC_1
0.7523
p.R272W
NCI-H1563
lung
COSMIC
ARTTS
DEG_SPOP_SBC_1
0.7523
Drug responses associated with CHAMP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15530
3-phosphoinositide-dependent protein kinase 1
DEG_SPOP_SBC_1
2:6
ARTTS
SPOP
0.9984
More...
P51826
AF4/FMR2 family member 3
DEG_SPOP_SBC_1
728:732
ARTTS
SPOP
0.5704
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2282:2286
ARTTS
SPOP
0.9001
More...
Q96JM3
Chromosome alignment-maintaining phosphoprotein 1
DEG_SPOP_SBC_1
271:275
ARTTS
SPOP
0.9868
More...
Q9UHR4
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
DEG_SPOP_SBC_1
456:460
ARTTS
SPOP
0.602
More...
Q86VZ1
P2Y purinoceptor 8
DEG_SPOP_SBC_1
328:332
ARTTS
SPOP
0.87
More...