DegronMD

Uniprot ID: O15530

Source protein: 3-phosphoinositide-dependent protein kinase 1

Source gene: PDPK1

Class: DEG_SPOP_SBC_1

Location: 2:6

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 97.64

COIL: 0.7394

CONS_SCORE: 0.4565

DSS_SCORE: 0.7032

HELIX: 0.2432

FCONS_SCORE: 1.1035

RIG_SCORE: 0.7755

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15530	3-phosphoinositide-dependent protein kinase 1	DEG_SPOP_SBC_1	2:6	ARTTS	SPOP	0.9984	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	728:732	ARTTS	SPOP	0.5704	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SPOP_SBC_1	456:460	ARTTS	SPOP	0.602	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SPOP_SBC_1	271:275	ARTTS	SPOP	0.9868	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2282:2286	ARTTS	SPOP	0.9001	More...
Q86VZ1	P2Y purinoceptor 8	DEG_SPOP_SBC_1	328:332	ARTTS	SPOP	0.87	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons