DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ARTTS
Uniprot ID:
O15530
Source protein:
3-phosphoinositide-dependent protein kinase 1
Source gene:
PDPK1
Class:
DEG_SPOP_SBC_1
Location:
2:6
E3 ligase:
SPOP
DEGRON score:
0.9984
ASA_SCORE:
97.64
COIL:
0.7394
CONS_SCORE:
0.4565
DSS_SCORE:
0.7032
HELIX:
0.2432
FCONS_SCORE:
1.1035
RIG_SCORE:
0.7755
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PDPK1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15530
3-phosphoinositide-dependent protein kinase 1
DEG_SPOP_SBC_1
2:6
ARTTS
SPOP
0.9984
More...
P51826
AF4/FMR2 family member 3
DEG_SPOP_SBC_1
728:732
ARTTS
SPOP
0.5704
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2282:2286
ARTTS
SPOP
0.9001
More...
Q96JM3
Chromosome alignment-maintaining phosphoprotein 1
DEG_SPOP_SBC_1
271:275
ARTTS
SPOP
0.9868
More...
Q9UHR4
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
DEG_SPOP_SBC_1
456:460
ARTTS
SPOP
0.602
More...
Q86VZ1
P2Y purinoceptor 8
DEG_SPOP_SBC_1
328:332
ARTTS
SPOP
0.87
More...