DegronMD

Uniprot ID: Q96JM3

Source protein: Chromosome alignment-maintaining phosphoprotein 1

Source gene: CHAMP1

Class: DEG_SCF_FBW7_1

Location: 167:173

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 96.8

COIL: 0.969

CONS_SCORE: 0.5199

DSS_SCORE: 0.7277

HELIX: 0.0123

FCONS_SCORE: 0.8648

RIG_SCORE: 0.5678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E175G	DO222737	COCA	ICGC	LQTPLPS	DEG_SCF_FBW7_1	0.2778
p.T169A	DO233620	GACA	ICGC	LQTPLPS	DEG_SCF_FBW7_1	0.825
p.E175D	DO229027	LICA	ICGC	LQTPLPS	DEG_SCF_FBW7_1	0.2778
p.P174S	SIDM01081	Oral Cavity Carcinoma	GDSC	LQTPLPS	DEG_SCF_FBW7_1	0.3056
p.P174S	SIDM00814	Other Solid Cancers	GDSC	LQTPLPS	DEG_SCF_FBW7_1	0.3056
p.A180V	SIDM01588	Endometrial Carcinoma	GDSC	LQTPLPS	DEG_SCF_FBW7_1	0.1389
p.A180V	ACH-000993	Endometrial/Uterine Cancer	CCLE	LQTPLPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_SCF_FBW7_1	167:173	LQTPLPS	FBXW7	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons