DegronMD

Uniprot ID: Q96JM3

Source protein: Chromosome alignment-maintaining phosphoprotein 1

Source gene: CHAMP1

Class: DEG_APCC_KENBOX_2

Location: 666:670

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9977

ASA_SCORE: 112.16

COIL: 0.7902

CONS_SCORE: 0.5715

DSS_SCORE: 0.6292

HELIX: 0.1852

FCONS_SCORE: 1.1063

RIG_SCORE: 0.6942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I663V	TCGA-34-2596	LUSC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.25
p.I663V	DO26508	LUSC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.25
p.D664V	TCGA-HU-A4GH	STAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.2778
p.D664V	DO47743	STAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.2778
p.D672G	TCGA-VQ-A91D	STAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.2778
p.D672G	DO51783	STAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.2778
p.E677D	DO228976	LICA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.1389
p.V660L	DO229019	LICA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.1667
p.R680K	DO231179	LUSC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.0556
p.E668A	DO228349	MALY	ICGC	SKENK	DEG_APCC_KENBOX_2	0.7701
p.E668A	SIDM00656	Burkitt's Lymphoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.7701
p.E668A	SIDM00641	Burkitt's Lymphoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.7701
p.E668A	ACH-000944	Lymphoma	CCLE	SKENK	DEG_APCC_KENBOX_2	0.7701
p.E668A	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.7701
p.M671I	SIDM00845	Burkitt's Lymphoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.M671I	SIDM00254	Neuroblastoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.T674A	NCI-H1975	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07947	Tyrosine-protein kinase Yes	DEG_APCC_KENBOX_2	6:10	SKENK	APC,CDC20,FZR1	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	2663:2667	SKENK	APC,CDC20,FZR1	0.913	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_APCC_KENBOX_2	666:670	SKENK	APC,CDC20,FZR1	0.9977	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_APCC_KENBOX_2	291:295	SKENK	APC,CDC20,FZR1	0.8688	More...
Q9P2Y5	UV radiation resistance-associated gene protein	DEG_APCC_KENBOX_2	558:562	SKENK	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons