DegronMD

Uniprot ID: P07947

Source protein: Tyrosine-protein kinase Yes

Source gene: YES1

Class: DEG_APCC_KENBOX_2

Location: 6:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 103.32

COIL: 0.791

CONS_SCORE: 0.448

DSS_SCORE: 0.6605

HELIX: 0.193

FCONS_SCORE: 1.1113

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2C	TCGA-A5-A2K5	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.6667
p.G2C	DO41379	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.6667
p.S6I	TCGA-AX-A2HC	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.623
p.S6I	DO41572	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.623
p.E8D	TCGA-CA-6718	COAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.6758
p.E8D	DO7801	COAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.6758
p.K10N	TCGA-EO-A22U	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.5806
p.K10N	DO43755	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.5806
p.R17I	TCGA-L9-A7SV	LUAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.1389
p.R17T	TCGA-LT-A5Z6	BLCA	TCGA	SKENK	DEG_APCC_KENBOX_2	0.1389
p.L4F	DO516	BLCA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.2778
p.L4F	DO14998	HNSC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.2778
p.M6V	DO51407	PRAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.7208
p.C3S	ACH-000659	Lung Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.25
p.C3S	ACH-001386	Lung Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07947	Tyrosine-protein kinase Yes	DEG_APCC_KENBOX_2	6:10	SKENK	APC,CDC20,FZR1	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	2663:2667	SKENK	APC,CDC20,FZR1	0.913	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_APCC_KENBOX_2	666:670	SKENK	APC,CDC20,FZR1	0.9977	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_APCC_KENBOX_2	291:295	SKENK	APC,CDC20,FZR1	0.8688	More...
Q9P2Y5	UV radiation resistance-associated gene protein	DEG_APCC_KENBOX_2	558:562	SKENK	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons