DegronMD - Q9P2Y5(UVRAG)

FUNCTION: Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. View more >>

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D567Y	TCGA-44-7670	LUAD	TCGA	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1944
p.D567Y	TCGA-50-6590	LUAD	TCGA	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1944
p.D567Y	DO24692	LUAD	ICGC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1944
p.D567Y	DO23555	LUAD	ICGC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1944
p.S548C	TCGA-AR-A1AO	BRCA	TCGA	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.0556
p.S548C	DO4443	BRCA	ICGC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.0556
p.E510K	TCGA-CR-7371	HNSC	TCGA	PPSY	ITCH	520:523	Mutation rewiring degron network	0.0556
p.E510K	DO15454	HNSC	ICGC	PPSY	ITCH	520:523	Mutation rewiring degron network	0.0556
p.P520H	TCGA-DA-A1IB	SKCM	TCGA	PPSY	ITCH	520:523	Mutation altering degron motif	0.7694
p.P520H	DO38033	SKCM	ICGC	PPSY	ITCH	520:523	Mutation altering degron motif	0.7694
p.S554F	TCGA-FW-A3R5	SKCM	TCGA	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation blocking phosphorylation signal	0.6667
p.S554F	DO37406	SKCM	ICGC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation blocking phosphorylation signal	0.6667
p.G565R	TCGA-SJ-A6ZI	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.25
p.G565R	DO219784	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.25
p.S525L	DO23160	LINC	ICGC	PPSY	ITCH	520:523	Mutation rewiring degron network	0.2778
p.V569L	SIDM00258	Neuroblastoma	GDSC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1389
p.V569L	NB12	autonomic ganglia	COSMIC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1389
p.L551F	SIDM00860	Head and Neck Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1389
p.L551F	FADU	upper aerodigestive tract	COSMIC	SKENK	DEG_APCC_KENBOX_2	558:562	Mutation rewiring degron network	0.1389
p.N524T	NY	bone	COSMIC	PPSY	ITCH	520:523	Mutation rewiring degron network	0.3056

Kaplan plot for UVRAG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UVRAG

UniProt ID: Q9P2Y5

Entrez ID: 7405

Protein name: UV radiation resistance-associated gene protein (p63)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UVRAG in