DegronMD

Uniprot ID: Q9P2Y5

Source protein: UV radiation resistance-associated gene protein

Source gene: UVRAG

Class: DEG_APCC_KENBOX_2

Location: 558:562

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9842

ASA_SCORE: 101.92

COIL: 0.6566

CONS_SCORE: 0.2506

DSS_SCORE: 0.4811

HELIX: 0.2892

FCONS_SCORE: 0.9866

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D567Y	TCGA-44-7670	LUAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.1944
p.D567Y	TCGA-50-6590	LUAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.1944
p.D567Y	DO24692	LUAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.1944
p.D567Y	DO23555	LUAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.1944
p.S548C	TCGA-AR-A1AO	BRCA	TCGA	SKENK	DEG_APCC_KENBOX_2	0.0556
p.S548C	DO4443	BRCA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.0556
p.S554F	TCGA-FW-A3R5	SKCM	TCGA	SKENK	DEG_APCC_KENBOX_2	0.6667
p.S554F	DO37406	SKCM	ICGC	SKENK	DEG_APCC_KENBOX_2	0.6667
p.G565R	TCGA-SJ-A6ZI	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.25
p.G565R	DO219784	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.25
p.V569L	SIDM00258	Neuroblastoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.1389
p.V569L	NB12	autonomic_ganglia	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.1389
p.L551F	SIDM00860	Head and Neck Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.1389
p.L551F	FADU	upper_aerodigestive_tract	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07947	Tyrosine-protein kinase Yes	DEG_APCC_KENBOX_2	6:10	SKENK	APC,CDC20,FZR1	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	2663:2667	SKENK	APC,CDC20,FZR1	0.913	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_APCC_KENBOX_2	666:670	SKENK	APC,CDC20,FZR1	0.9977	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_APCC_KENBOX_2	291:295	SKENK	APC,CDC20,FZR1	0.8688	More...
Q9P2Y5	UV radiation resistance-associated gene protein	DEG_APCC_KENBOX_2	558:562	SKENK	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons