DegronMD - Q5VT06(CEP350)

FUNCTION: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.

GO - Biological processes (BP): microtubule anchoring [GO:0034453]; non-motile cilium assembly [GO:1905515]; protein localization to centrosome [GO:0071539]

GO - Molecular function (MF): microtubule binding [GO:0008017]

GO - Cellular component (CC): cell projection [GO:0042995]; centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle [GO:0005819]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R529L	TCGA-GN-A4U9	SKCM	TCGA	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8428
p.R529L	DO50304	SKCM	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8428
p.R529C	TCGA-EO-A22R	UCEC	TCGA	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8301
p.R529C	DO222685	BTCA	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8301
p.R529C	DO222880	MELA	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8301
p.R529C	DO42713	UCEC	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8301
p.R529C	ACH-000172	Rhabdoid	CCLE	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8301
p.R529H	TCGA-AX-A06F	UCEC	TCGA	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8244
p.R529H	DO41752	UCEC	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.8244
p.S1274F	TCGA-ER-A19F	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1271:1275	Mutation altering degron motif	0.7982
p.S1274F	DO37679	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1271:1275	Mutation altering degron motif	0.7982
p.S2484F	TCGA-FS-A1ZQ	SKCM	TCGA	TESPSLASVPTA	DEG_COP1_1	2480:2491	Mutation altering degron motif	0.7982
p.S2484F	DO37442	SKCM	ICGC	TESPSLASVPTA	DEG_COP1_1	2480:2491	Mutation altering degron motif	0.7982
p.S2158F	DO220899	MELA	ICGC	SRGSLESIA	DEG_APCC_DBOX_1	2158:2166	Mutation altering degron motif	0.7982
p.A51D	DO229275	THCA	ICGC	APTST	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7793
p.P1910H	TCGA-ER-A19F	SKCM	TCGA	PKTPKKE	DEG_SCF_FBW7_2	1907:1913	Mutation altering degron motif	0.7694
p.P1910H	DO37679	SKCM	ICGC	PKTPKKE	DEG_SCF_FBW7_2	1907:1913	Mutation altering degron motif	0.7694
p.S1274A	TCGA-ER-A19F	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1271:1275	Mutation altering degron motif	0.7588
p.S1274A	DO37679	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1271:1275	Mutation altering degron motif	0.7588
p.S2158C	SIDM01174	Cervical Carcinoma	GDSC	SRGSLESIA	DEG_APCC_DBOX_1	2158:2166	Mutation altering degron motif	0.7541

Showing 1 to 20 of 145 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP350

UniProt ID: Q5VT06

Entrez ID: 9857

Protein name: Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP350 in