DegronMD

Uniprot ID: Q5VT06

Source protein: Centrosome-associated protein 350

Source gene: CEP350

Class: DEG_APCC_KENBOX_2

Location: 1557:1561

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.951

ASA_SCORE: 104.56

COIL: 0.7186

CONS_SCORE: 0.4337

DSS_SCORE: 0.6615

HELIX: 0.235

FCONS_SCORE: 0.994

RIG_SCORE: 0.6527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1549R	TCGA-56-6545	LUSC	TCGA	CKENE	DEG_APCC_KENBOX_2	0.1111
p.Q1549R	DO26532	LUSC	ICGC	CKENE	DEG_APCC_KENBOX_2	0.1111
p.P1555S	TCGA-D3-A51G	SKCM	TCGA	CKENE	DEG_APCC_KENBOX_2	0.2778
p.P1555S	DO47700	SKCM	ICGC	CKENE	DEG_APCC_KENBOX_2	0.2778
p.P1555L	TCGA-D9-A6EC	SKCM	TCGA	CKENE	DEG_APCC_KENBOX_2	0.2778
p.P1555L	DO50291	SKCM	ICGC	CKENE	DEG_APCC_KENBOX_2	0.2778
p.K1568N	TCGA-ZF-AA4X	BLCA	TCGA	CKENE	DEG_APCC_KENBOX_2	0.25
p.K1568N	DO219091	BLCA	ICGC	CKENE	DEG_APCC_KENBOX_2	0.25
p.K1568N	SIDM00992	Thyroid Gland Carcinoma	GDSC	CKENE	DEG_APCC_KENBOX_2	0.25
p.K1568N	ACH-000456	Thyroid Cancer	CCLE	CKENE	DEG_APCC_KENBOX_2	0.25
p.K1568N	BCPAP	thyroid	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.25
p.P1552L	SIDM00149	Melanoma	GDSC	CKENE	DEG_APCC_KENBOX_2	0.1944
p.P1552L	ACH-000750	Skin Cancer	CCLE	CKENE	DEG_APCC_KENBOX_2	0.1944
p.P1552L	LOXIMVI	skin	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	1557:1561	CKENE	APC,CDC20,FZR1	0.951	More...
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_APCC_KENBOX_2	345:349	CKENE	APC,CDC20,FZR1	0.5557	More...
Q9BRU2	Transcription elongation factor A protein-like 7	DEG_APCC_KENBOX_2	5:9	CKENE	APC,CDC20,FZR1	0.7442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons