DegronMD

Uniprot ID: Q9BRU2

Source protein: Transcription elongation factor A protein-like 7

Source gene: TCEAL7

Class: DEG_APCC_KENBOX_2

Location: 5:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7442

ASA_SCORE: 110.66

COIL: 0.6912

CONS_SCORE: 0.8186

DSS_SCORE: 0.7077

HELIX: 0.3218

FCONS_SCORE: 1.0023

RIG_SCORE: 0.633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R19W	TCGA-CV-6952	HNSC	TCGA	CKENE	DEG_APCC_KENBOX_2	0.0556
p.R19W	DO14240	HNSC	ICGC	CKENE	DEG_APCC_KENBOX_2	0.0556
p.R19S	DO229038	LICA	ICGC	CKENE	DEG_APCC_KENBOX_2	0.0556
p.E9K	DO222390	MELA	ICGC	CKENE	DEG_APCC_KENBOX_2	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	1557:1561	CKENE	APC,CDC20,FZR1	0.951	More...
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_APCC_KENBOX_2	345:349	CKENE	APC,CDC20,FZR1	0.5557	More...
Q9BRU2	Transcription elongation factor A protein-like 7	DEG_APCC_KENBOX_2	5:9	CKENE	APC,CDC20,FZR1	0.7442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons