DegronMD - Q86UL8(MAGI2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R553Q	TCGA-13-0911	OV	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.R553Q	TCGA-2L-AAQJ	PAAD	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.R553Q	TCGA-B5-A1MX	UCEC	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.R553Q	DO233873	GACA	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.R553Q	DO31553	OV	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.R553Q	DO218949	PAAD	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.R553Q	DO41999	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6218
p.P1111T	TCGA-17-Z055	LUAD	TCGA	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.2778
p.R564Q	TCGA-25-2398	OV	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564Q	DO220851	MELA	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564Q	DO31250	OV	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.D258A	TCGA-3N-A9WC	SKCM	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2222
p.A261T	TCGA-44-3918	LUAD	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1389
p.L527I	TCGA-49-AARE	LUAD	TCGA	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1389
p.L527I	DO218922	LUAD	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1389
p.D1113Y	TCGA-60-2714	LUSC	TCGA	DYR	CBL_MET	1113:1115	Mutation altering degron motif	0.7325
p.D1113Y	DO26530	LUSC	ICGC	DYR	CBL_MET	1113:1115	Mutation altering degron motif	0.7325
p.Y1122C	TCGA-66-2744	LUSC	TCGA	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1389
p.Y1122C	TCGA-FI-A2D0	UCEC	TCGA	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1389
p.Y1122C	DO27025	LUSC	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1389
p.Y1122C	DO43891	UCEC	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1389
p.P565L	TCGA-66-2794	LUSC	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.P565L	TCGA-BR-4362	STAD	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.P565L	DO26683	LUSC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.P565L	DO38336	STAD	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.S552Y	TCGA-AA-3984	COAD	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.712
p.S552Y	DO9002	COAD	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.712
p.P341S	TCGA-AP-A056	UCEC	TCGA	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2222
p.P341S	DO43971	UCEC	ICGC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2222
p.P251S	TCGA-AP-A1DV	UCEC	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation altering degron motif	0.6752
p.P251S	DO43186	UCEC	ICGC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation altering degron motif	0.6752
p.E343K	TCGA-B2-5639	KIRC	TCGA	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2778
p.E343K	DO19803	KIRC	ICGC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2778
p.I203V	TCGA-CN-A63U	HNSC	TCGA	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.2778
p.I203V	DO44454	HNSC	ICGC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.2778
p.L195I	TCGA-D1-A17Q	UCEC	TCGA	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.0556
p.L195I	DO41903	UCEC	ICGC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.0556
p.P565Q	TCGA-D3-A3C8	SKCM	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.P565Q	DO47636	SKCM	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.R215W	TCGA-D5-5541	COAD	TCGA	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.25
p.R215W	DO10475	COAD	ICGC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.25
p.H1125Q	TCGA-DK-AA76	BLCA	TCGA	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.0556
p.H1125Q	DO219013	BLCA	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.0556
p.E355K	TCGA-EE-A29M	SKCM	TCGA	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.1667
p.E355K	TCGA-Z2-A8RT	SKCM	TCGA	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.1667
p.E355K	DO37404	SKCM	ICGC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.1667
p.E355K	DO51301	SKCM	ICGC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.1667
p.Y547N	TCGA-EE-A3AA	SKCM	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation blocking phosphorylation signal	0.6389
p.Y547N	TCGA-EE-A3AA	SKCM	TCGA	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation blocking phosphorylation signal	0.5278
p.Y547N	DO222632	MELA	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation blocking phosphorylation signal	0.6389
p.Y547N	DO222632	MELA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation blocking phosphorylation signal	0.5278
p.Y547N	DO37571	SKCM	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation blocking phosphorylation signal	0.6389
p.Y547N	DO37571	SKCM	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation blocking phosphorylation signal	0.5278
p.R564W	TCGA-EO-A22R	UCEC	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	DO229462	SKCA	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	DO42713	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	DO42673	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	SIDM00336	Melanoma	GDSC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	SIDM00217	Colorectal Carcinoma	GDSC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	ACH-000881	Skin Cancer	CCLE	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	ACH-000999	Colon/Colorectal Cancer	CCLE	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	MEL-JUSO	skin	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R564W	SNU-1040	large intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.D563E	TCGA-F5-6814	READ	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2778
p.D563E	DO36556	READ	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2778
p.V536A	TCGA-FF-8043	DLBC	TCGA	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.6936
p.V536A	DO222308	DLBC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.6936
p.P565T	TCGA-FG-7643	LGG	TCGA	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.P565T	DO22394	LGG	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2222
p.V241A	TCGA-FI-A2D5	UCEC	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1667
p.V241A	DO41331	UCEC	ICGC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1667
p.N245S	TCGA-G4-6320	COAD	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.N245S	DO8159	COAD	ICGC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.K346N	TCGA-VQ-A91D	STAD	TCGA	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation altering degron motif	0.6918
p.K346N	DO51783	STAD	ICGC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation altering degron motif	0.6918
p.D258G	TCGA-W2-A7HD	PCPG	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2222
p.P240L	TCGA-W3-AA21	SKCM	TCGA	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1389
p.P240L	DO51278	SKCM	ICGC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1389
p.D1113H	DO224547	BRCA	ICGC	DYR	CBL_MET	1113:1115	Mutation altering degron motif	0.7688
p.D1113H	DO1001	BRCA	ICGC	DYR	CBL_MET	1113:1115	Mutation altering degron motif	0.7688
p.P209S	DO234239	ESAD	ICGC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation altering degron motif	0.6752
p.G540V	DO218484	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2778
p.D563Y	DO233038	GACA	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.2778
p.V542A	DO233174	GACA	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.0556
p.V542A	DO233174	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2222
p.V542A	DO43907	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.0556
p.V542A	DO43907	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2222
p.R532S	DO233262	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2778
p.G532C	DO233674	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2778
p.N551I	DO11501	GBM	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.3056
p.D1121E	DO228952	LICA	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1667
p.P1117H	DO229026	LICA	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.2778
p.G1103V	DO229053	LICA	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.0556
p.I554M	DO48743	LIRI	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.7618
p.P1111L	DO231018	LUSC	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.2778
p.P1111L	DO220856	MELA	ICGC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.2778
p.R1115K	DO222363	MELA	ICGC	DYR	CBL_MET	1113:1115	Mutation altering degron motif	0.7237
p.M530I	DO222702	MELA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2222
p.E237K	DO222875	MELA	ICGC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.0556
p.K529N	DO30970	OV	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1944
p.Q202H	DO32904	PACA	ICGC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.25
p.I554K	DO36491	READ	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.7531
p.S537L	DO219503	SKCM	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.7667
p.L555I	DO41572	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.7174
p.V542I	DO43907	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.0556
p.V542I	DO43907	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2222
p.I541T	DO42793	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.25
p.S555L	SIDM02017	Colorectal Carcinoma	GDSC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6556
p.H256R	SIDM00222	Mesothelioma	GDSC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.H256R	ACH-000319	Lung Cancer	CCLE	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.H256R	MPP-89	pleura	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.D560N	SIDM01483	Melanoma	GDSC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6932
p.D560N	ACH-000582	Skin Cancer	CCLE	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6932
p.D560N	COLO-741	large intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.6932
p.A263V	SIDM01146	Gastric Carcinoma	GDSC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.0833
p.A263V	ACH-000932	Gastric Cancer	CCLE	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.0833
p.A263V	NCI-SNU-1	stomach	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.0833
p.A528S	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1667
p.A528S	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1667
p.A528S	ACH-000590	Lung Cancer	CCLE	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1667
p.A528S	ACH-001137	Lung Cancer	CCLE	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1667
p.A528S	NCI-H1993	lung	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1667
p.G1104R	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.0833
p.G1104R	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.0833
p.R532K	SIDM01611	Endometrial Carcinoma	GDSC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2778
p.R532K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2778
p.E347K	SIDM01611	Endometrial Carcinoma	GDSC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation altering degron motif	0.7022
p.D241E	NUGC-3	stomach	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1667
p.P1111S	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.2778
p.C197W	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.1111
p.T542P	MZ1-PC	pancreas	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.0556
p.T542P	MZ1-PC	pancreas	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2222
p.F547I	HT55	large intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation blocking phosphorylation signal	0.6389
p.F547I	HT55	large intestine	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation blocking phosphorylation signal	0.5278
p.G538E	5637	urinary tract	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.7199
p.G538E	BC-3	haematopoietic and lymphoid tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.7199
p.A220V	NUGC-3	stomach	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.1111
p.T358M	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.0833
p.D526G	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1111
p.R534Q	SNU-C2B	large intestine	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.7329
p.S530G	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.2222
p.R245Q	BFTC-905	urinary tract	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.S1121T	HCC-15	lung	COSMIC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1667
p.D337N	COLO-741	large intestine	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation substituting flanking lysine	0.2222
p.D350H	UDSCC2	upper aerodigestive tract	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.3056
p.N340Y	GP5d	large intestine	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation substituting flanking lysine	0.3056
p.E536K	NCI-H2009	lung	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation altering degron motif	0.7022
p.R254W	SNU-1040	large intestine	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation altering degron motif	0.8634
p.R254W	MEL-JUSO	skin	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation altering degron motif	0.8634
p.P216H	LP-1	haematopoietic and lymphoid tissue	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation substituting flanking lysine	0.3333
p.P1106L	NCI-H1770	lung	COSMIC	DYR	CBL_MET	1113:1115	Mutation blocking phosphorylation signal	0.5833
p.R549H	SNU-1040	large intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.R549H	NCI-H2141	lung	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation rewiring degron network	0.25
p.P241H	LP-1	haematopoietic and lymphoid tissue	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1667
p.V524G	ATN-1	haematopoietic and lymphoid tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.0556
p.V352G	ATN-1	haematopoietic and lymphoid tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.25
p.R341W	MEL-JUSO	skin	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2222
p.R341W	SNU-1040	large intestine	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.2222
p.A245V	NUGC-3	stomach	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.2778
p.I541K	HCC-366	lung	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.25
p.I528V	MFE-296	endometrium	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation rewiring degron network	0.1667
p.C344W	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.3056
p.S547F	MCC13	skin	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation blocking phosphorylation signal	0.6389
p.S547F	MCC13	skin	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	534:538	Mutation blocking phosphorylation signal	0.5278
p.G345V	NCI-H2342	lung	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation altering degron motif	0.7532
p.R559Q	SNU-C2B	large intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	552:561	Mutation altering degron motif	0.7329
p.D354G	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	345:349	Mutation rewiring degron network	0.1944
p.A218S	NCI-H1993	lung	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	205:212	Mutation rewiring degron network	0.1667
p.G260V	NCI-H2342	lung	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation rewiring degron network	0.1667
p.P1107T	KYSE-220	oesophagus	COSMIC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.1667
p.A1110T	OC-314	ovary	COSMIC	DYR	CBL_MET	1113:1115	Mutation rewiring degron network	0.25
p.D250N	COLO-741	large intestine	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	247:254	Mutation altering degron motif	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGI2

UniProt ID: Q86UL8

Entrez ID: 9863

Protein name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGI2 in