DegronMD

Uniprot ID: Q86UL8

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Source gene: MAGI2

Class: DEG_SCF_FBW7_1

Location: 247:254

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 77.1875

COIL: 0.7466

CONS_SCORE: 0.4957

DSS_SCORE: 0.7406

HELIX: 0.0471

FCONS_SCORE: 1.0699

RIG_SCORE: 0.6416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D258A	TCGA-3N-A9WC	SKCM	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.2222
p.A261T	TCGA-44-3918	LUAD	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.1389
p.P251S	TCGA-AP-A1DV	UCEC	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.6752
p.P251S	DO43186	UCEC	ICGC	VVVTPESS	DEG_SCF_FBW7_1	0.6752
p.V241A	TCGA-FI-A2D5	UCEC	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.1667
p.V241A	DO41331	UCEC	ICGC	VVVTPESS	DEG_SCF_FBW7_1	0.1667
p.N245S	TCGA-G4-6320	COAD	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.N245S	DO8159	COAD	ICGC	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.D258G	TCGA-W2-A7HD	PCPG	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.2222
p.P240L	TCGA-W3-AA21	SKCM	TCGA	VVVTPESS	DEG_SCF_FBW7_1	0.1389
p.P240L	DO51278	SKCM	ICGC	VVVTPESS	DEG_SCF_FBW7_1	0.1389
p.E237K	DO222875	MELA	ICGC	VVVTPESS	DEG_SCF_FBW7_1	0.0556
p.H256R	SIDM00222	Mesothelioma	GDSC	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.H256R	ACH-000319	Lung Cancer	CCLE	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.H256R	MPP-89	pleura	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.A263V	SIDM01146	Gastric Carcinoma	GDSC	VVVTPESS	DEG_SCF_FBW7_1	0.0833
p.A263V	ACH-000932	Gastric Cancer	CCLE	VVVTPESS	DEG_SCF_FBW7_1	0.0833
p.A263V	NCI-SNU-1	stomach	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.0833
p.D241E	NUGC-3	stomach	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.1667
p.R245Q	BFTC-905	urinary_tract	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.R254W	SNU-1040	large_intestine	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.8634
p.R254W	MEL-JUSO	skin	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.8634
p.P241H	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.1667
p.A245V	NUGC-3	stomach	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.2778
p.G260V	NCI-H2342	lung	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.1667
p.D250N	COLO-741	large_intestine	COSMIC	VVVTPESS	DEG_SCF_FBW7_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_SCF_FBW7_1	247:254	VVVTPESS	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVVTPESS

Degron related mutations and impact score

Drug responses associated with MAGI2 mutations

All proteins holding degron of VVVTPESS