DegronMD

Uniprot ID: Q86UL8

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Source gene: MAGI2

Class: DEG_SCF_FBW7_2

Location: 205:212

E3 ligase: FBXW7

DEGRON score: 0.9746

ASA_SCORE: 73.4

COIL: 0.8954

CONS_SCORE: 0.497

DSS_SCORE: 0.5957

HELIX: 0.065

FCONS_SCORE: 0.999

RIG_SCORE: 0.6391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I203V	TCGA-CN-A63U	HNSC	TCGA	PGATPSAE	DEG_SCF_FBW7_2	0.2778
p.I203V	DO44454	HNSC	ICGC	PGATPSAE	DEG_SCF_FBW7_2	0.2778
p.L195I	TCGA-D1-A17Q	UCEC	TCGA	PGATPSAE	DEG_SCF_FBW7_2	0.0556
p.L195I	DO41903	UCEC	ICGC	PGATPSAE	DEG_SCF_FBW7_2	0.0556
p.R215W	TCGA-D5-5541	COAD	TCGA	PGATPSAE	DEG_SCF_FBW7_2	0.25
p.R215W	DO10475	COAD	ICGC	PGATPSAE	DEG_SCF_FBW7_2	0.25
p.P209S	DO234239	ESAD	ICGC	PGATPSAE	DEG_SCF_FBW7_2	0.6752
p.Q202H	DO32904	PACA	ICGC	PGATPSAE	DEG_SCF_FBW7_2	0.25
p.C197W	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	0.1111
p.A220V	NUGC-3	stomach	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	0.1111
p.P216H	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	0.3333
p.A218S	NCI-H1993	lung	COSMIC	PGATPSAE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_SCF_FBW7_2	205:212	PGATPSAE	FBXW7	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons