DegronMD

Uniprot ID: Q86UL8

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Source gene: MAGI2

Class: DEG_Kelch_actinfilin_1

Location: 534:538

E3 ligase: CUL3,KLHL17

DEGRON score: 0.9834

ASA_SCORE: 72.94

COIL: 0.763

CONS_SCORE: 0.4998

DSS_SCORE: 0.3602

HELIX: 0.0298

FCONS_SCORE: 1.0903

RIG_SCORE: 0.6999

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L527I	TCGA-49-AARE	LUAD	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.1389
p.L527I	DO218922	LUAD	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.1389
p.Y547N	TCGA-EE-A3AA	SKCM	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.5278
p.Y547N	DO222632	MELA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.5278
p.Y547N	DO37571	SKCM	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.5278
p.V536A	TCGA-FF-8043	DLBC	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.6936
p.V536A	DO222308	DLBC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.6936
p.G540V	DO218484	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2778
p.V542A	DO233174	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.V542A	DO43907	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.R532S	DO233262	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2778
p.G532C	DO233674	GACA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2778
p.M530I	DO222702	MELA	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.K529N	DO30970	OV	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.1944
p.S537L	DO219503	SKCM	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.7667
p.V542I	DO43907	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.I541T	DO42793	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.25
p.A528S	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PPVMV	DEG_Kelch_actinfilin_1	0.1667
p.A528S	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	PPVMV	DEG_Kelch_actinfilin_1	0.1667
p.A528S	ACH-000590	Lung Cancer	CCLE	PPVMV	DEG_Kelch_actinfilin_1	0.1667
p.A528S	ACH-001137	Lung Cancer	CCLE	PPVMV	DEG_Kelch_actinfilin_1	0.1667
p.A528S	NCI-H1993	lung	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.1667
p.R532K	SIDM01611	Endometrial Carcinoma	GDSC	PPVMV	DEG_Kelch_actinfilin_1	0.2778
p.R532K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPVMV	DEG_Kelch_actinfilin_1	0.2778
p.T542P	MZ1-PC	pancreas	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.F547I	HT55	large_intestine	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.5278
p.G538E	5637	urinary_tract	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.7199
p.G538E	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.7199
p.D526G	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.1111
p.R534Q	SNU-C2B	large_intestine	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.7329
p.S530G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.E536K	NCI-H2009	lung	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.7022
p.V524G	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.0556
p.I541K	HCC-366	lung	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.25
p.I528V	MFE-296	endometrium	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.1667
p.S547F	MCC13	skin	COSMIC	PPVMV	DEG_Kelch_actinfilin_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_Kelch_actinfilin_1	359:363	PPVMV	CUL3,KLHL17	0.7112	More...
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_Kelch_actinfilin_1	534:538	PPVMV	CUL3,KLHL17	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVMV

Degron related mutations and impact score

Drug responses associated with MAGI2 mutations

All proteins holding degron of PPVMV