DegronMD - O14776(TCERG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A323V	TCGA-97-7938	LUAD	TCGA	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.5825
p.A323V	DO24329	LUAD	ICGC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.5825
p.P324L	TCGA-97-7938	LUAD	TCGA	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.6471
p.P324L	DO24329	LUAD	ICGC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.6471
p.Q350E	TCGA-AA-3511	COAD	TCGA	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.0833
p.Q350E	DO7804	COAD	ICGC	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.0833
p.S281P	TCGA-AA-A01P	COAD	TCGA	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.6752
p.S281P	DO8642	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.6752
p.A293V	TCGA-AG-A002	READ	TCGA	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.A293V	TCGA-IN-8462	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.A293V	DO48012	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.A293V	SIDM01609	Endometrial Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.A293V	ACH-000972	Endometrial/Uterine Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.R367C	TCGA-AN-A046	BRCA	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	DO1285	BRCA	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	DO234217	ESAD	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	SIDM01079	Melanoma	GDSC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	ACH-000441	Skin Cancer	CCLE	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.R367C	SH-4	skin	COSMIC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8301
p.P351S	TCGA-CJ-5682	KIRC	TCGA	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.1111
p.P351S	DO18056	KIRC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.1111
p.I355L	TCGA-D1-A103	UCEC	TCGA	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.2222
p.I355L	DO42312	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.2222
p.R367H	TCGA-D1-A103	UCEC	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.R367H	DO42312	UCEC	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.P365S	TCGA-D3-A51J	SKCM	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.3056
p.P365S	TCGA-D3-A51J	SKCM	TCGA	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.2778
p.P365S	DO47359	SKCM	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.3056
p.P365S	DO47359	SKCM	ICGC	PPVMV	DEG_Kelch_actinfilin_1	359:363	Mutation rewiring degron network	0.2778
p.M382I	TCGA-DD-AA3A	LIHC	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1111
p.M382I	DO52192	LIHC	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1111
p.S281C	DO225319	BRCA	ICGC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7541
p.P261S	DO225253	BRCA	ICGC	PTTSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6752
p.Q330R	DO228246	BRCA	ICGC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation rewiring degron network	0.1944
p.M373L	DO228278	LICA	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.5999
p.T321I	DO228896	LICA	ICGC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7078
p.A269S	DO228974	LICA	ICGC	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7588
p.S318I	DO228974	LICA	ICGC	VATPTVS	DEG_SCF_FBW7_1	312:318	Mutation altering degron motif	0.7341
p.A293S	DO228971	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.T278A	DO220912	MELA	ICGC	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.T278A	DO220912	MELA	ICGC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.3056
p.I375V	DO46795	PRAD	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.3056
p.P382S	DO42033	UCEC	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1111
p.T321A	SIDM00845	Burkitt's Lymphoma	GDSC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T321A	SIDM00461	Acute Myeloid Leukemia	GDSC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T321A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T321A	SIDM01519	Head and Neck Carcinoma	GDSC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T321A	ACH-000786	Lymphoma	CCLE	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T321A	ACH-000992	Head and Neck Cancer	CCLE	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T321A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation altering degron motif	0.7139
p.T274K	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.T274K	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.T274K	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1944
p.T274K	SIDM01680	Non-Cancerous	GDSC	PTTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.T274K	SIDM01680	Non-Cancerous	GDSC	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.T274K	SIDM01680	Non-Cancerous	GDSC	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1944
p.T274K	ACH-000251	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.T274K	ACH-000251	Lung Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.T274K	ACH-000251	Lung Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1944
p.T274K	ACH-000589	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.T274K	ACH-000589	Lung Cancer	CCLE	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.T274K	ACH-000589	Lung Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1944
p.T274K	ACH-002364	Non-Cancerous	CCLE	PTTSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.T274K	ACH-002364	Non-Cancerous	CCLE	AVSTS	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.T274K	ACH-002364	Non-Cancerous	CCLE	PSSTT	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1944
p.P328H	SIDM00839	Colorectal Carcinoma	GDSC	VATPTVS	DEG_SCF_FBW7_1	312:318	Mutation rewiring degron network	0.0556
p.P328H	SIDM00839	Colorectal Carcinoma	GDSC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation rewiring degron network	0.25
p.P328H	ACH-000950	Colon/Colorectal Cancer	CCLE	VATPTVS	DEG_SCF_FBW7_1	312:318	Mutation rewiring degron network	0.0556
p.P328H	ACH-000950	Colon/Colorectal Cancer	CCLE	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation rewiring degron network	0.25
p.P328H	LoVo	large intestine	COSMIC	VATPTVS	DEG_SCF_FBW7_1	312:318	Mutation rewiring degron network	0.0556
p.P328H	LoVo	large intestine	COSMIC	VSTPAPT	DEG_SCF_FBW7_1	319:325	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCERG1

UniProt ID: O14776

Entrez ID: 10915

Protein name: Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCERG1 in