DegronMD

Uniprot ID: O14776

Source protein: Transcription elongation regulator 1

Source gene: TCERG1

Class: DEG_SCF_FBW7_1

Location: 312:318

E3 ligase: FBXW7

DEGRON score: 0.989

ASA_SCORE: 77.6571

COIL: 0.928

CONS_SCORE: 0.2925

DSS_SCORE: 0.5351

HELIX: 0.0257

FCONS_SCORE: 0.9085

RIG_SCORE: 0.673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S318I	DO228974	LICA	ICGC	VATPTVS	DEG_SCF_FBW7_1	0.7341
p.P328H	SIDM00839	Colorectal Carcinoma	GDSC	VATPTVS	DEG_SCF_FBW7_1	0.0556
p.P328H	ACH-000950	Colon/Colorectal Cancer	CCLE	VATPTVS	DEG_SCF_FBW7_1	0.0556
p.P328H	LoVo	large_intestine	COSMIC	VATPTVS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SCF_FBW7_1	312:318	VATPTVS	FBXW7	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons