DegronMD

Uniprot ID: O14776

Source protein: Transcription elongation regulator 1

Source gene: TCERG1

Class: DEG_APCC_DBOX_1

Location: 366:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7888

ASA_SCORE: 86.1222

COIL: 0.961

CONS_SCORE: 0.341

DSS_SCORE: 0.1366

HELIX: 0.018

FCONS_SCORE: 1.0073

RIG_SCORE: 0.7519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R367C	TCGA-AN-A046	BRCA	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	0.8301
p.R367C	DO1285	BRCA	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.8301
p.R367C	DO234217	ESAD	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.8301
p.R367C	SIDM01079	Melanoma	GDSC	FRVPLPGMP	DEG_APCC_DBOX_1	0.8301
p.R367C	ACH-000441	Skin Cancer	CCLE	FRVPLPGMP	DEG_APCC_DBOX_1	0.8301
p.R367C	SH-4	skin	COSMIC	FRVPLPGMP	DEG_APCC_DBOX_1	0.8301
p.R367H	TCGA-D1-A103	UCEC	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	0.8244
p.R367H	DO42312	UCEC	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.8244
p.P365S	TCGA-D3-A51J	SKCM	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	0.3056
p.P365S	DO47359	SKCM	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.3056
p.M382I	TCGA-DD-AA3A	LIHC	TCGA	FRVPLPGMP	DEG_APCC_DBOX_1	0.1111
p.M382I	DO52192	LIHC	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.1111
p.M373L	DO228278	LICA	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.5999
p.I375V	DO46795	PRAD	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.3056
p.P382S	DO42033	UCEC	ICGC	FRVPLPGMP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_APCC_DBOX_1	366:374	FRVPLPGMP	APC,CDC20,FZR1	0.7888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons