DegronMD

Uniprot ID: O14776

Source protein: Transcription elongation regulator 1

Source gene: TCERG1

Class: DEG_Kelch_actinfilin_1

Location: 359:363

E3 ligase: CUL3,KLHL17

DEGRON score: 0.7112

ASA_SCORE: 89.08

COIL: 0.9702

CONS_SCORE: 0.3379

DSS_SCORE: 0.2362

HELIX: 0.014

FCONS_SCORE: 1.011

RIG_SCORE: 0.7426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q350E	TCGA-AA-3511	COAD	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.0833
p.Q350E	DO7804	COAD	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.0833
p.P351S	TCGA-CJ-5682	KIRC	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.1111
p.P351S	DO18056	KIRC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.1111
p.I355L	TCGA-D1-A103	UCEC	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.I355L	DO42312	UCEC	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2222
p.P365S	TCGA-D3-A51J	SKCM	TCGA	PPVMV	DEG_Kelch_actinfilin_1	0.2778
p.P365S	DO47359	SKCM	ICGC	PPVMV	DEG_Kelch_actinfilin_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_Kelch_actinfilin_1	359:363	PPVMV	CUL3,KLHL17	0.7112	More...
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_Kelch_actinfilin_1	534:538	PPVMV	CUL3,KLHL17	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons