DegronMD

Uniprot ID: O14776

Source protein: Transcription elongation regulator 1

Source gene: TCERG1

Class: DEG_SCF_FBW7_1

Location: 319:325

E3 ligase: FBXW7

DEGRON score: 0.988

ASA_SCORE: 79.8

COIL: 0.9446

CONS_SCORE: 0.3071

DSS_SCORE: 0.5563

HELIX: 0.0219

FCONS_SCORE: 0.9907

RIG_SCORE: 0.621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A323V	TCGA-97-7938	LUAD	TCGA	VSTPAPT	DEG_SCF_FBW7_1	0.5825
p.A323V	DO24329	LUAD	ICGC	VSTPAPT	DEG_SCF_FBW7_1	0.5825
p.P324L	TCGA-97-7938	LUAD	TCGA	VSTPAPT	DEG_SCF_FBW7_1	0.6471
p.P324L	DO24329	LUAD	ICGC	VSTPAPT	DEG_SCF_FBW7_1	0.6471
p.Q330R	DO228246	BRCA	ICGC	VSTPAPT	DEG_SCF_FBW7_1	0.1944
p.T321I	DO228896	LICA	ICGC	VSTPAPT	DEG_SCF_FBW7_1	0.7078
p.T321A	SIDM00845	Burkitt's Lymphoma	GDSC	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.T321A	SIDM00461	Acute Myeloid Leukemia	GDSC	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.T321A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.T321A	SIDM01519	Head and Neck Carcinoma	GDSC	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.T321A	ACH-000786	Lymphoma	CCLE	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.T321A	ACH-000992	Head and Neck Cancer	CCLE	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.T321A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPAPT	DEG_SCF_FBW7_1	0.7139
p.P328H	SIDM00839	Colorectal Carcinoma	GDSC	VSTPAPT	DEG_SCF_FBW7_1	0.25
p.P328H	ACH-000950	Colon/Colorectal Cancer	CCLE	VSTPAPT	DEG_SCF_FBW7_1	0.25
p.P328H	LoVo	large_intestine	COSMIC	VSTPAPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SCF_FBW7_1	319:325	VSTPAPT	FBXW7	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons