DegronMD

Uniprot ID: Q86UL8

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Source gene: MAGI2

Class: DEG_COP1_1

Location: 552:561

E3 ligase: COP1

DEGRON score: 0.9774

ASA_SCORE: 79.72

COIL: 0.8516

CONS_SCORE: 0.4629

DSS_SCORE: 0.5433

HELIX: 0.1048

FCONS_SCORE: 0.9454

RIG_SCORE: 0.692

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R553Q	TCGA-13-0911	OV	TCGA	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R553Q	TCGA-2L-AAQJ	PAAD	TCGA	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R553Q	TCGA-B5-A1MX	UCEC	TCGA	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R553Q	DO233873	GACA	ICGC	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R553Q	DO31553	OV	ICGC	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R553Q	DO218949	PAAD	ICGC	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R553Q	DO41999	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.6218
p.R564Q	TCGA-25-2398	OV	TCGA	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564Q	DO220851	MELA	ICGC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564Q	DO31250	OV	ICGC	SRTSQSVPDI	DEG_COP1_1	0.25
p.P565L	TCGA-66-2794	LUSC	TCGA	SRTSQSVPDI	DEG_COP1_1	0.2222
p.P565L	TCGA-BR-4362	STAD	TCGA	SRTSQSVPDI	DEG_COP1_1	0.2222
p.P565L	DO26683	LUSC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.2222
p.P565L	DO38336	STAD	ICGC	SRTSQSVPDI	DEG_COP1_1	0.2222
p.S552Y	TCGA-AA-3984	COAD	TCGA	SRTSQSVPDI	DEG_COP1_1	0.712
p.S552Y	DO9002	COAD	ICGC	SRTSQSVPDI	DEG_COP1_1	0.712
p.P565Q	TCGA-D3-A3C8	SKCM	TCGA	SRTSQSVPDI	DEG_COP1_1	0.2222
p.P565Q	DO47636	SKCM	ICGC	SRTSQSVPDI	DEG_COP1_1	0.2222
p.Y547N	TCGA-EE-A3AA	SKCM	TCGA	SRTSQSVPDI	DEG_COP1_1	0.6389
p.Y547N	DO222632	MELA	ICGC	SRTSQSVPDI	DEG_COP1_1	0.6389
p.Y547N	DO37571	SKCM	ICGC	SRTSQSVPDI	DEG_COP1_1	0.6389
p.R564W	TCGA-EO-A22R	UCEC	TCGA	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	DO229462	SKCA	ICGC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	DO42713	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	DO42673	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	SIDM00336	Melanoma	GDSC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	SIDM00217	Colorectal Carcinoma	GDSC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	ACH-000881	Skin Cancer	CCLE	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	ACH-000999	Colon/Colorectal Cancer	CCLE	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	MEL-JUSO	skin	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R564W	SNU-1040	large_intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.25
p.D563E	TCGA-F5-6814	READ	TCGA	SRTSQSVPDI	DEG_COP1_1	0.2778
p.D563E	DO36556	READ	ICGC	SRTSQSVPDI	DEG_COP1_1	0.2778
p.P565T	TCGA-FG-7643	LGG	TCGA	SRTSQSVPDI	DEG_COP1_1	0.2222
p.P565T	DO22394	LGG	ICGC	SRTSQSVPDI	DEG_COP1_1	0.2222
p.D563Y	DO233038	GACA	ICGC	SRTSQSVPDI	DEG_COP1_1	0.2778
p.V542A	DO233174	GACA	ICGC	SRTSQSVPDI	DEG_COP1_1	0.0556
p.V542A	DO43907	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.0556
p.N551I	DO11501	GBM	ICGC	SRTSQSVPDI	DEG_COP1_1	0.3056
p.I554M	DO48743	LIRI	ICGC	SRTSQSVPDI	DEG_COP1_1	0.7618
p.I554K	DO36491	READ	ICGC	SRTSQSVPDI	DEG_COP1_1	0.7531
p.L555I	DO41572	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.7174
p.V542I	DO43907	UCEC	ICGC	SRTSQSVPDI	DEG_COP1_1	0.0556
p.S555L	SIDM02017	Colorectal Carcinoma	GDSC	SRTSQSVPDI	DEG_COP1_1	0.6556
p.D560N	SIDM01483	Melanoma	GDSC	SRTSQSVPDI	DEG_COP1_1	0.6932
p.D560N	ACH-000582	Skin Cancer	CCLE	SRTSQSVPDI	DEG_COP1_1	0.6932
p.D560N	COLO-741	large_intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.6932
p.T542P	MZ1-PC	pancreas	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.0556
p.F547I	HT55	large_intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.6389
p.R549H	SNU-1040	large_intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.25
p.R549H	NCI-H2141	lung	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.25
p.S547F	MCC13	skin	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.6389
p.R559Q	SNU-C2B	large_intestine	COSMIC	SRTSQSVPDI	DEG_COP1_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRTSQSVPDI

Degron related mutations and impact score

Drug responses associated with MAGI2 mutations

All proteins holding degron of SRTSQSVPDI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_COP1_1	552:561	SRTSQSVPDI	COP1	0.9774	More...