DegronMD

Uniprot ID: Q86UL8

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Source gene: MAGI2

Class: DEG_APCC_KENBOX_2

Location: 345:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5557

ASA_SCORE: 85.86

COIL: 0.67

CONS_SCORE: 0.5359

DSS_SCORE: 0.424

HELIX: 0.2046

FCONS_SCORE: 0.9152

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P341S	TCGA-AP-A056	UCEC	TCGA	CKENE	DEG_APCC_KENBOX_2	0.2222
p.P341S	DO43971	UCEC	ICGC	CKENE	DEG_APCC_KENBOX_2	0.2222
p.E343K	TCGA-B2-5639	KIRC	TCGA	CKENE	DEG_APCC_KENBOX_2	0.2778
p.E343K	DO19803	KIRC	ICGC	CKENE	DEG_APCC_KENBOX_2	0.2778
p.E355K	TCGA-EE-A29M	SKCM	TCGA	CKENE	DEG_APCC_KENBOX_2	0.1667
p.E355K	TCGA-Z2-A8RT	SKCM	TCGA	CKENE	DEG_APCC_KENBOX_2	0.1667
p.E355K	DO37404	SKCM	ICGC	CKENE	DEG_APCC_KENBOX_2	0.1667
p.E355K	DO51301	SKCM	ICGC	CKENE	DEG_APCC_KENBOX_2	0.1667
p.K346N	TCGA-VQ-A91D	STAD	TCGA	CKENE	DEG_APCC_KENBOX_2	0.6918
p.K346N	DO51783	STAD	ICGC	CKENE	DEG_APCC_KENBOX_2	0.6918
p.E347K	SIDM01611	Endometrial Carcinoma	GDSC	CKENE	DEG_APCC_KENBOX_2	0.7022
p.T358M	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.0833
p.D337N	COLO-741	large_intestine	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.2222
p.D350H	UDSCC2	upper_aerodigestive_tract	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.3056
p.N340Y	GP5d	large_intestine	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.3056
p.V352G	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.25
p.R341W	MEL-JUSO	skin	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.2222
p.R341W	SNU-1040	large_intestine	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.2222
p.C344W	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.3056
p.G345V	NCI-H2342	lung	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.7532
p.D354G	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	CKENE	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	1557:1561	CKENE	APC,CDC20,FZR1	0.951	More...
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	DEG_APCC_KENBOX_2	345:349	CKENE	APC,CDC20,FZR1	0.5557	More...
Q9BRU2	Transcription elongation factor A protein-like 7	DEG_APCC_KENBOX_2	5:9	CKENE	APC,CDC20,FZR1	0.7442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons