DegronMD

Uniprot ID: Q5VT06

Source protein: Centrosome-associated protein 350

Source gene: CEP350

Class: DEG_COP1_1

Location: 2480:2491

E3 ligase: COP1

DEGRON score: 0.9605

ASA_SCORE: 78.75

COIL: 0.804

CONS_SCORE: 0.3565

DSS_SCORE: 0.5209

HELIX: 0.1408

FCONS_SCORE: 0.8661

RIG_SCORE: 0.6998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2470C	TCGA-AX-A0J1	UCEC	TCGA	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470C	TCGA-BR-7703	STAD	TCGA	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470C	DO38232	STAD	ICGC	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470C	DO41199	UCEC	ICGC	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470C	SIDM01619	Endometrial Carcinoma	GDSC	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470C	ACH-000984	Endometrial/Uterine Cancer	CCLE	TESPSLASVPTA	DEG_COP1_1	0.0556
p.P2483L	TCGA-CA-6717	COAD	TCGA	TESPSLASVPTA	DEG_COP1_1	0.6471
p.P2483L	DO8264	COAD	ICGC	TESPSLASVPTA	DEG_COP1_1	0.6471
p.S2484F	TCGA-FS-A1ZQ	SKCM	TCGA	TESPSLASVPTA	DEG_COP1_1	0.7982
p.S2484F	DO37442	SKCM	ICGC	TESPSLASVPTA	DEG_COP1_1	0.7982
p.A2491T	DO6519	CLLE	ICGC	TESPSLASVPTA	DEG_COP1_1	0.7139
p.F2497Y	DO30750	OV	ICGC	TESPSLASVPTA	DEG_COP1_1	0.1667
p.P2483S	SIDM00266	Ewing's Sarcoma	GDSC	TESPSLASVPTA	DEG_COP1_1	0.5641
p.P2483S	ACH-002103	Bone Cancer	CCLE	TESPSLASVPTA	DEG_COP1_1	0.5641
p.P2483S	ES1	bone	COSMIC	TESPSLASVPTA	DEG_COP1_1	0.5641
p.R2470H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470H	ACH-000938	Leukemia	CCLE	TESPSLASVPTA	DEG_COP1_1	0.0556
p.R2470H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	TESPSLASVPTA	DEG_COP1_1	0.0556
p.G2500D	SIDM00516	Melanoma	GDSC	TESPSLASVPTA	DEG_COP1_1	0.0833
p.G2500D	ACH-002166	Skin Cancer	CCLE	TESPSLASVPTA	DEG_COP1_1	0.0833
p.G2500D	MZ7-mel	skin	COSMIC	TESPSLASVPTA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_COP1_1	2480:2491	TESPSLASVPTA	COP1	0.9605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons