DegronMD

Uniprot ID: Q5VT06

Source protein: Centrosome-associated protein 350

Source gene: CEP350

Class: DEG_SCF_FBW7_2

Location: 1907:1913

E3 ligase: FBXW7

DEGRON score: 0.9663

ASA_SCORE: 112.1429

COIL: 0.7813

CONS_SCORE: 0.4087

DSS_SCORE: 0.5609

HELIX: 0.212

FCONS_SCORE: 1.0181

RIG_SCORE: 0.6875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1916N	TCGA-44-2662	LUAD	TCGA	PKTPKKE	DEG_SCF_FBW7_2	0.25
p.D1916N	DO26290	LUAD	ICGC	PKTPKKE	DEG_SCF_FBW7_2	0.25
p.W1900C	TCGA-AD-A5EJ	COAD	TCGA	PKTPKKE	DEG_SCF_FBW7_2	0.1389
p.W1900C	DO50090	COAD	ICGC	PKTPKKE	DEG_SCF_FBW7_2	0.1389
p.W1900L	TCGA-DA-A1IB	SKCM	TCGA	PKTPKKE	DEG_SCF_FBW7_2	0.1389
p.W1900L	DO38033	SKCM	ICGC	PKTPKKE	DEG_SCF_FBW7_2	0.1389
p.P1910H	TCGA-ER-A19F	SKCM	TCGA	PKTPKKE	DEG_SCF_FBW7_2	0.7694
p.P1910H	DO37679	SKCM	ICGC	PKTPKKE	DEG_SCF_FBW7_2	0.7694
p.D1901Y	SIDM01261	Breast Carcinoma	GDSC	PKTPKKE	DEG_SCF_FBW7_2	0.1667
p.D1901Y	SIDM00314	Breast Carcinoma	GDSC	PKTPKKE	DEG_SCF_FBW7_2	0.1667
p.D1901Y	ACH-000097	Breast Cancer	CCLE	PKTPKKE	DEG_SCF_FBW7_2	0.1667
p.D1901Y	ACH-002208	Breast Cancer	CCLE	PKTPKKE	DEG_SCF_FBW7_2	0.1667
p.D1901Y	YMB-1-E	breast	COSMIC	PKTPKKE	DEG_SCF_FBW7_2	0.1667
p.D1916Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PKTPKKE	DEG_SCF_FBW7_2	0.25
p.D1916Y	ACH-000951	Lung Cancer	CCLE	PKTPKKE	DEG_SCF_FBW7_2	0.25
p.D1916Y	NCI-H2342	lung	COSMIC	PKTPKKE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_SCF_FBW7_2	1907:1913	PKTPKKE	FBXW7	0.9663	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons