DegronMD

Uniprot ID: Q5VT06

Source protein: Centrosome-associated protein 350

Source gene: CEP350

Class: DEG_APCC_DBOX_1

Location: 2158:2166

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9546

ASA_SCORE: 78.4111

COIL: 0.6621

CONS_SCORE: 0.3561

DSS_SCORE: 0.4794

HELIX: 0.3041

FCONS_SCORE: 0.9688

RIG_SCORE: 0.656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2163Q	TCGA-IC-A6RE	ESCA	TCGA	SRGSLESIA	DEG_APCC_DBOX_1	0.5633
p.R2157H	DO233624	GACA	ICGC	SRGSLESIA	DEG_APCC_DBOX_1	0.3056
p.G2175C	DO229041	LICA	ICGC	SRGSLESIA	DEG_APCC_DBOX_1	0.0833
p.S2164C	DO25010	LUAD	ICGC	SRGSLESIA	DEG_APCC_DBOX_1	0.643
p.S2158F	DO220899	MELA	ICGC	SRGSLESIA	DEG_APCC_DBOX_1	0.7982
p.S2158C	SIDM01174	Cervical Carcinoma	GDSC	SRGSLESIA	DEG_APCC_DBOX_1	0.7541
p.S2158C	ACH-001402	Cervical Cancer	CCLE	SRGSLESIA	DEG_APCC_DBOX_1	0.7541
p.S2158C	SW756	cervix	COSMIC	SRGSLESIA	DEG_APCC_DBOX_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_APCC_DBOX_1	2158:2166	SRGSLESIA	APC,CDC20,FZR1	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons