DegronMD

Uniprot ID: Q5VT06

Source protein: Centrosome-associated protein 350

Source gene: CEP350

Class: DEG_APCC_KENBOX_2

Location: 2663:2667

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.913

ASA_SCORE: 104.42

COIL: 0.63

CONS_SCORE: 0.3563

DSS_SCORE: 0.5079

HELIX: 0.3402

FCONS_SCORE: 0.9817

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2662P	TCGA-60-2703	LUSC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.3056
p.S2662P	DO27715	LUSC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.S2671F	TCGA-BS-A0UV	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.6667
p.S2671F	DO218863	SKCA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.6667
p.S2671F	DO42793	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.6667
p.K2667E	TCGA-CA-6717	COAD	TCGA	SKENK	DEG_APCC_KENBOX_2	0.591
p.K2667E	DO8264	COAD	ICGC	SKENK	DEG_APCC_KENBOX_2	0.591
p.S2662Y	TCGA-E6-A1M0	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.3056
p.S2662Y	DO43682	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.I2670V	SIDM01199	Hepatocellular Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.25
p.I2670V	SIDM01756	Chronic Myelogenous Leukemia	GDSC	SKENK	DEG_APCC_KENBOX_2	0.25
p.S2659L	SIDM00789	Colorectal Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.2222
p.S2659L	ACH-000997	Colon/Colorectal Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.2222
p.S2659L	HCT-15	large_intestine	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.2222
p.E2665G	SIDM00160	Biliary Tract Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.7199
p.T2674I	ACH-000954	Endometrial/Uterine Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07947	Tyrosine-protein kinase Yes	DEG_APCC_KENBOX_2	6:10	SKENK	APC,CDC20,FZR1	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	2663:2667	SKENK	APC,CDC20,FZR1	0.913	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_APCC_KENBOX_2	666:670	SKENK	APC,CDC20,FZR1	0.9977	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_APCC_KENBOX_2	291:295	SKENK	APC,CDC20,FZR1	0.8688	More...
Q9P2Y5	UV radiation resistance-associated gene protein	DEG_APCC_KENBOX_2	558:562	SKENK	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons