DegronMD

Uniprot ID: Q9NPI1

Source protein: Bromodomain-containing protein 7

Source gene: BRD7

Class: DEG_APCC_KENBOX_2

Location: 291:295

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8688

ASA_SCORE: 110.92

COIL: 0.704

CONS_SCORE: 0.3551

DSS_SCORE: 0.6331

HELIX: 0.2918

FCONS_SCORE: 0.9631

RIG_SCORE: 0.5854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D298H	TCGA-B5-A11E	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.25
p.D298H	DO41644	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.25
p.P290L	TCGA-DA-A1HY	SKCM	TCGA	SKENK	DEG_APCC_KENBOX_2	0.3056
p.P290L	TCGA-FI-A2D0	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.3056
p.P290L	DO37409	SKCM	ICGC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.P290L	DO43891	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.K296N	TCGA-DD-A39Z	LIHC	TCGA	SKENK	DEG_APCC_KENBOX_2	0.3056
p.K296N	DO44954	LIHC	ICGC	SKENK	DEG_APCC_KENBOX_2	0.3056
p.A282T	TCGA-EW-A1PH	BRCA	TCGA	SKENK	DEG_APCC_KENBOX_2	0.0833
p.A282T	DO2551	BRCA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.0833
p.S291N	DO50970	LICA	ICGC	SKENK	DEG_APCC_KENBOX_2	0.7069
p.A284T	SIDM00534	Colorectal Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.1389
p.A284T	ACH-000986	Colon/Colorectal Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.1389
p.A284T	HT-115	large_intestine	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.1389
p.K299N	SIDM00205	Ewing's Sarcoma	GDSC	SKENK	DEG_APCC_KENBOX_2	0.3333
p.K299N	ACH-002110	Bone Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.3333
p.S289T	ACH-002287	Colon/Colorectal Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	0.7222
p.S289T	NCI-H630	large_intestine	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.7222
p.N294K	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.N294K	JIMT-1	breast	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.N294K	no-10	central_nervous_system	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.N294K	NCI-H2342	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.N294K	NCI-H2196	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.N294K	HT-1080	soft_tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.N294K	NCI-H1048	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.6918
p.K295E	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07947	Tyrosine-protein kinase Yes	DEG_APCC_KENBOX_2	6:10	SKENK	APC,CDC20,FZR1	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_APCC_KENBOX_2	2663:2667	SKENK	APC,CDC20,FZR1	0.913	More...
Q96JM3	Chromosome alignment-maintaining phosphoprotein 1	DEG_APCC_KENBOX_2	666:670	SKENK	APC,CDC20,FZR1	0.9977	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_APCC_KENBOX_2	291:295	SKENK	APC,CDC20,FZR1	0.8688	More...
Q9P2Y5	UV radiation resistance-associated gene protein	DEG_APCC_KENBOX_2	558:562	SKENK	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENK

Degron related mutations and impact score

Drug responses associated with BRD7 mutations

All proteins holding degron of SKENK