DegronMD - Q9NPI1(BRD7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P117S	TCGA-18-3409	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.P117S	DO26444	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.Q133H	TCGA-AA-3852	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.Q133H	DO8471	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.D298H	TCGA-B5-A11E	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.25
p.D298H	DO41644	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.25
p.P290L	TCGA-DA-A1HY	SKCM	TCGA	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.3056
p.P290L	TCGA-FI-A2D0	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.3056
p.P290L	DO37409	SKCM	ICGC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.3056
p.P290L	DO43891	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.3056
p.K296N	TCGA-DD-A39Z	LIHC	TCGA	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.3056
p.K296N	DO44954	LIHC	ICGC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.3056
p.A282T	TCGA-EW-A1PH	BRCA	TCGA	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.0833
p.A282T	DO2551	BRCA	ICGC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.0833
p.P110L	TCGA-FW-A3R5	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.P110L	DO37406	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.S123N	DO231795	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7069
p.S291N	DO50970	LICA	ICGC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.7069
p.P110S	DO222458	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.P116S	DO229257	THCA	ICGC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2222
p.S123R	SIDM02021	Esophageal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7427
p.L125I	SIDM00625	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.L125I	SIDM01044	Other Solid Cancers	GDSC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.Q128R	SIDM00217	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2222
p.Q128R	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2222
p.Q128R	SNU-1040	large intestine	COSMIC	PLTSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2222
p.A284T	SIDM00534	Colorectal Carcinoma	GDSC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.1389
p.A284T	ACH-000986	Colon/Colorectal Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.1389
p.A284T	HT-115	large intestine	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation rewiring degron network	0.1389
p.K299N	SIDM00205	Ewing's Sarcoma	GDSC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation substituting flanking lysine	0.3333
p.K299N	ACH-002110	Bone Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation substituting flanking lysine	0.3333
p.S289T	ACH-002287	Colon/Colorectal Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation blocking phosphorylation signal	0.7222
p.S289T	NCI-H630	large intestine	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation blocking phosphorylation signal	0.7222
p.N294K	ATN-1	haematopoietic and lymphoid tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.N294K	JIMT-1	breast	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.N294K	no-10	central nervous system	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.N294K	NCI-H2342	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.N294K	NCI-H2196	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.N294K	HT-1080	soft tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.N294K	NCI-H1048	lung	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.6918
p.K295E	ATN-1	haematopoietic and lymphoid tissue	COSMIC	SKENK	DEG_APCC_KENBOX_2	291:295	Mutation altering degron motif	0.591

Kaplan plot for BRD7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRD7

UniProt ID: Q9NPI1

Entrez ID: 29117

Protein name: Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRD7 in