DegronMD - P07947(YES1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G2C	TCGA-A5-A2K5	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation blocking phosphorylation signal	0.6667
p.G2C	DO41379	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation blocking phosphorylation signal	0.6667
p.S6I	TCGA-AX-A2HC	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.623
p.S6I	DO41572	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.623
p.P22T	TCGA-B5-A0K0	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.P22T	SIDM01155	Glioma	GDSC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.P22T	ACH-000437	Brain Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.P22T	SW1088	central nervous system	COSMIC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.E8D	TCGA-CA-6718	COAD	TCGA	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.6758
p.E8D	DO7801	COAD	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.6758
p.P24S	TCGA-D3-A8GM	SKCM	TCGA	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.6752
p.K10N	TCGA-EO-A22U	UCEC	TCGA	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.5806
p.K10N	DO43755	UCEC	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.5806
p.R17I	TCGA-L9-A7SV	LUAD	TCGA	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.1389
p.R17I	TCGA-L9-A7SV	LUAD	TCGA	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.R17T	TCGA-LT-A5Z6	BLCA	TCGA	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.1389
p.R17T	TCGA-LT-A5Z6	BLCA	TCGA	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.R22T	DO44029	BLCA	ICGC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.L4F	DO516	BLCA	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.2778
p.L4F	DO14998	HNSC	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.2778
p.G33A	DO23466	LINC	ICGC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1944
p.R22I	DO49875	LUAD	ICGC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.M6V	DO51407	PRAD	ICGC	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.7208
p.P29S	DO50288	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.3056
p.P27T	DO42440	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.7031
p.P27T	SW1088	central nervous system	COSMIC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.7031
p.P22S	SIDM02012	Colorectal Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.2778
p.Y32C	SIDM00994	T-Lymphoblastic Leukemia	GDSC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation blocking phosphorylation signal	0.6667
p.Y32C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation blocking phosphorylation signal	0.6667
p.S26N	SIDM01608	Endometrial Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.818
p.S26N	ACH-000990	Endometrial/Uterine Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.818
p.C3S	ACH-000659	Lung Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.25
p.C3S	ACH-001386	Lung Cancer	CCLE	SKENK	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.25
p.Y37C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	24:28	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for YES1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YES1

UniProt ID: P07947

Entrez ID: 7525

Protein name: Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YES1 in