DegronMD

Uniprot ID: Q5VT06

Source protein: Centrosome-associated protein 350

Source gene: CEP350

Class: DEG_APCC_DBOX_1

Location: 528:536

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7063

ASA_SCORE: 78.4556

COIL: 0.4583

CONS_SCORE: 0.6179

DSS_SCORE: 0.2882

HELIX: 0.4828

FCONS_SCORE: 1.6011

RIG_SCORE: 0.8194

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R529H	TCGA-AX-A06F	UCEC	TCGA	IRGILDDLQ	DEG_APCC_DBOX_1	0.8244
p.R529H	DO41752	UCEC	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.8244
p.R529C	TCGA-EO-A22R	UCEC	TCGA	IRGILDDLQ	DEG_APCC_DBOX_1	0.8301
p.R529C	DO222685	BTCA	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.8301
p.R529C	DO222880	MELA	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.8301
p.R529C	DO42713	UCEC	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.8301
p.R529C	ACH-000172	Rhabdoid	CCLE	IRGILDDLQ	DEG_APCC_DBOX_1	0.8301
p.R529L	TCGA-GN-A4U9	SKCM	TCGA	IRGILDDLQ	DEG_APCC_DBOX_1	0.8428
p.R529L	DO50304	SKCM	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.8428
p.G530V	DO228934	LICA	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.6421
p.D534Y	DO229034	LICA	ICGC	IRGILDDLQ	DEG_APCC_DBOX_1	0.6214
p.D522G	SIDM00969	Ovarian Carcinoma	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.1667
p.D522G	SIDM00650	Small Cell Lung Carcinoma	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.1667
p.D522G	SIDM00971	Breast Carcinoma	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.1667
p.D522G	SIDM01133	Other Solid Cancers	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.1667
p.D522G	SIDM01681	Non-Cancerous	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.1667
p.D522G	SIDM00628	Breast Carcinoma	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.1667
p.I526M	SIDM00188	Kidney Carcinoma	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.2778
p.I526M	ACH-002139	Kidney Cancer	CCLE	IRGILDDLQ	DEG_APCC_DBOX_1	0.2778
p.I526M	HA7-RCC	kidney	COSMIC	IRGILDDLQ	DEG_APCC_DBOX_1	0.2778
p.I531V	SIDM00650	Small Cell Lung Carcinoma	GDSC	IRGILDDLQ	DEG_APCC_DBOX_1	0.5965
p.I531V	ACH-002286	Lung Cancer	CCLE	IRGILDDLQ	DEG_APCC_DBOX_1	0.5965
p.I531V	NCI-H128	lung	COSMIC	IRGILDDLQ	DEG_APCC_DBOX_1	0.5965
p.K521N	ACH-000901	Lung Cancer	CCLE	IRGILDDLQ	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VT06	Centrosome-associated protein 350	DEG_APCC_DBOX_1	528:536	IRGILDDLQ	APC,CDC20,FZR1	0.7063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRGILDDLQ

Degron related mutations and impact score

Drug responses associated with CEP350 mutations

All proteins holding degron of IRGILDDLQ