DegronMD

Uniprot ID: P51826

Source protein: AF4/FMR2 family member 3

Source gene: AFF3

Class: DEG_APCC_DBOX_1

Location: 385:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8094

ASA_SCORE: 105.6889

COIL: 0.4068

CONS_SCORE: 0.4704

DSS_SCORE: 0.5925

HELIX: 0.5721

FCONS_SCORE: 0.9988

RIG_SCORE: 0.7436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E379D	TCGA-AP-A0LM	UCEC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	0.1667
p.E379D	DO43306	UCEC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.1667
p.A376V	TCGA-AX-A1C5	UCEC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	0.0833
p.D394N	TCGA-B5-A3FA	UCEC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	0.3056
p.S380N	TCGA-EK-A2PM	CESC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	0.1944
p.D400N	TCGA-EK-A2RC	CESC	TCGA	QRTALRALS	DEG_APCC_DBOX_1	0.1389
p.D400N	DO49945	CESC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.1389
p.A376T	TCGA-FD-A3N5	BLCA	TCGA	QRTALRALS	DEG_APCC_DBOX_1	0.0833
p.D394V	DO50064	BRCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.3056
p.R390C	DO227668	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.719
p.R390C	DO38723	STAD	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.719
p.R390C	DO42073	UCEC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.719
p.S383N	DO229010	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.2778
p.S383N	DO229013	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.2778
p.S383N	DO229016	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.2778
p.S383N	DO229003	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.2778
p.S383N	DO229005	COCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.2778
p.G384C	DO234350	ESAD	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.3056
p.A376E	DO228974	LICA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.0833
p.T385K	DO229031	LICA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.7306
p.E380D	DO52326	LIHC	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.1944
p.V397M	DO229275	THCA	ICGC	QRTALRALS	DEG_APCC_DBOX_1	0.2222
p.S389L	SIDM00545	Melanoma	GDSC	QRTALRALS	DEG_APCC_DBOX_1	0.7667
p.S389L	Mewo	skin	COSMIC	QRTALRALS	DEG_APCC_DBOX_1	0.7667
p.S393A	ACH-000786	Lymphoma	CCLE	QRTALRALS	DEG_APCC_DBOX_1	0.7588
p.L389P	ACH-000989	Colon/Colorectal Cancer	CCLE	QRTALRALS	DEG_APCC_DBOX_1	0.7582
p.L389P	SNU-175	large_intestine	COSMIC	QRTALRALS	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51826	AF4/FMR2 family member 3	DEG_APCC_DBOX_1	385:393	QRTALRALS	APC,CDC20,FZR1	0.8094	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRTALRALS

Degron related mutations and impact score

Drug responses associated with AFF3 mutations

All proteins holding degron of QRTALRALS