DegronMD

Uniprot ID: P51826

Source protein: AF4/FMR2 family member 3

Source gene: AFF3

Class: DEG_SPOP_SBC_1

Location: 846:850

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 82.06

COIL: 0.9176

CONS_SCORE: 0.4515

DSS_SCORE: 0.5469

HELIX: 0.063

FCONS_SCORE: 1.0916

RIG_SCORE: 0.6589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R846L	TCGA-56-7222	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.8428
p.K858R	TCGA-CV-5439	HNSC	TCGA	ATSTS	DEG_SPOP_SBC_1	0.1111
p.E851K	TCGA-DM-A28H	COAD	TCGA	ATSTS	DEG_SPOP_SBC_1	0.3056
p.E851K	DO8906	COAD	ICGC	ATSTS	DEG_SPOP_SBC_1	0.3056
p.C848R	TCGA-HC-7080	PRAD	TCGA	ATSTS	DEG_SPOP_SBC_1	0.8301
p.C848R	DO36378	PRAD	ICGC	ATSTS	DEG_SPOP_SBC_1	0.8301
p.Q836H	DO230343	COCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.0556
p.E838D	DO14990	HNSC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.1111
p.N859S	DO229353	LAML	ICGC	ATSTS	DEG_SPOP_SBC_1	0.0833
p.G837R	DO231145	LUSC	ICGC	ATSTS	DEG_SPOP_SBC_1	0.0833
p.R844W	DO229268	THCA	ICGC	ATSTS	DEG_SPOP_SBC_1	0.2778
p.R855M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ATSTS	DEG_SPOP_SBC_1	0.1944
p.R855M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ATSTS	DEG_SPOP_SBC_1	0.1944
p.R855M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	0.1944
p.C848Y	SIDM01409	Bladder Carcinoma	GDSC	ATSTS	DEG_SPOP_SBC_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43167	Zinc finger and BTB domain-containing protein 24	DEG_SPOP_SBC_1	661:665	ATSTS	SPOP	0.8818	More...
O75061	Putative tyrosine-protein phosphatase auxilin	DEG_SPOP_SBC_1	564:568	ATSTS	SPOP	0.9989	More...
P51826	AF4/FMR2 family member 3	DEG_SPOP_SBC_1	846:850	ATSTS	SPOP	0.9984	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2250:2254	ATSTS	SPOP	0.9964	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	658:662	ATSTS	SPOP	0.6439	More...
Q3T8J9	GON-4-like protein	DEG_SPOP_SBC_1	2218:2222	ATSTS	SPOP	0.6171	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1706:1710	ATSTS	SPOP	0.8956	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1170:1174	ATSTS	SPOP	0.9971	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	238:242	ATSTS	SPOP	0.9886	More...
Q96IZ7	Serine/Arginine-related protein 53	DEG_SPOP_SBC_1	263:267	ATSTS	SPOP	0.9754	More...
Q9NQC1	E3 ubiquitin-protein ligase Jade-2	DEG_SPOP_SBC_1	22:26	ATSTS	SPOP	0.9861	More...
Q9NQG7	Hermansky-Pudlak syndrome 4 protein	DEG_SPOP_SBC_1	2:6	ATSTS	SPOP	0.7449	More...
Q9NR71	Neutral ceramidase	DEG_SPOP_SBC_1	701:705	ATSTS	SPOP	0.7751	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	840:844	ATSTS	SPOP	0.7206	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	1908:1912	ATSTS	SPOP	0.702	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	2690:2694	ATSTS	SPOP	0.9814	More...
Q9Y5P4	Ceramide transfer protein	DEG_SPOP_SBC_1	145:149	ATSTS	SPOP	0.9864	More...
Q96T17	MAP7 domain-containing protein 2	DEG_SPOP_SBC_1	229:233	ATSTS	SPOP	0.9487	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	26:30	ATSTS	SPOP	0.881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSTS

Degron related mutations and impact score

Drug responses associated with AFF3 mutations

All proteins holding degron of ATSTS