DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ATSTS
Uniprot ID:
Q9Y5P4
Source protein:
Ceramide transfer protein
Source gene:
CERT1
Class:
DEG_SPOP_SBC_1
Location:
145:149
E3 ligase:
SPOP
DEGRON score:
0.9864
ASA_SCORE:
66.48
COIL:
0.682
CONS_SCORE:
0.5693
DSS_SCORE:
0.3989
HELIX:
0.2252
FCONS_SCORE:
1.0346
RIG_SCORE:
0.6547
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CERT1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ATSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43167
Zinc finger and BTB domain-containing protein 24
DEG_SPOP_SBC_1
661:665
ATSTS
SPOP
0.8818
More...
O75061
Putative tyrosine-protein phosphatase auxilin
DEG_SPOP_SBC_1
564:568
ATSTS
SPOP
0.9989
More...
P51826
AF4/FMR2 family member 3
DEG_SPOP_SBC_1
846:850
ATSTS
SPOP
0.9984
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
2250:2254
ATSTS
SPOP
0.9964
More...
Q13164
Mitogen-activated protein kinase 7
DEG_SPOP_SBC_1
658:662
ATSTS
SPOP
0.6439
More...
Q3T8J9
GON-4-like protein
DEG_SPOP_SBC_1
2218:2222
ATSTS
SPOP
0.6171
More...
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1706:1710
ATSTS
SPOP
0.8956
More...
Q70CQ4
Ubiquitin carboxyl-terminal hydrolase 31
DEG_SPOP_SBC_1
1170:1174
ATSTS
SPOP
0.9971
More...
Q8IYB3
Serine/arginine repetitive matrix protein 1
DEG_SPOP_SBC_1
238:242
ATSTS
SPOP
0.9886
More...
Q96IZ7
Serine/Arginine-related protein 53
DEG_SPOP_SBC_1
263:267
ATSTS
SPOP
0.9754
More...
Q9NQC1
E3 ubiquitin-protein ligase Jade-2
DEG_SPOP_SBC_1
22:26
ATSTS
SPOP
0.9861
More...
Q9NQG7
Hermansky-Pudlak syndrome 4 protein
DEG_SPOP_SBC_1
2:6
ATSTS
SPOP
0.7449
More...
Q9NR71
Neutral ceramidase
DEG_SPOP_SBC_1
701:705
ATSTS
SPOP
0.7751
More...
Q9NZM3
Intersectin-2
DEG_SPOP_SBC_1
840:844
ATSTS
SPOP
0.7206
More...
Q9UKL3
CASP8-associated protein 2
DEG_SPOP_SBC_1
1908:1912
ATSTS
SPOP
0.702
More...
Q9Y520
Protein PRRC2C
DEG_SPOP_SBC_1
2690:2694
ATSTS
SPOP
0.9814
More...
Q9Y5P4
Ceramide transfer protein
DEG_SPOP_SBC_1
145:149
ATSTS
SPOP
0.9864
More...
Q96T17
MAP7 domain-containing protein 2
DEG_SPOP_SBC_1
229:233
ATSTS
SPOP
0.9487
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
26:30
ATSTS
SPOP
0.881
More...