DegronMD - Q9UKL3(CASP8AP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q902H	SIDM01293	Colorectal Carcinoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.2222
p.Q902H	SIDM01293	Colorectal Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.25
p.Y914S	SIDM00994	T-Lymphoblastic Leukemia	GDSC	NKENQ	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.2222
p.Y914S	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	NKENQ	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.2222
p.H886L	SIDM01245	T-Lymphoblastic Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0833
p.H886L	SIDM00991	T-Lymphoblastic Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0833
p.H886L	BE-13	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0833
p.N906S	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.5958
p.N906S	SIDM00970	Bladder Carcinoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.5958
p.N906S	TK	haematopoietic and lymphoid tissue	COSMIC	NKENQ	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.5958
p.V1918A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ATSTS	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1667
p.V1918A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ATSTS	DEG_SPOP_SBC_1	1908:1912	Mutation rewiring degron network	0.1667
p.P805S	SIDM00945	Colorectal Carcinoma	GDSC	VIVTPLVE	DEG_SCF_FBW7_2	790:797	Mutation rewiring degron network	0.1111
p.P805S	CL-34	large intestine	COSMIC	VIVTPLVE	DEG_SCF_FBW7_2	790:797	Mutation rewiring degron network	0.1111
p.Q1558H	SIDM00660	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1550:1554	Mutation rewiring degron network	0.2222
p.Q1558H	LS-411N	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	1550:1554	Mutation rewiring degron network	0.2222
p.R1252C	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.1389
p.H1257Q	SIDM00530	Esophageal Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.2778
p.C1258S	SIDM00530	Esophageal Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.3056
p.E1255G	SIDM00898	Breast Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.2222
p.E1255G	AU565	breast	COSMIC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.2222
p.D1563E	SIDM00618	Hepatocellular Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	1550:1554	Mutation rewiring degron network	0.0833
p.D1563E	JHH-1	liver	COSMIC	PSTSS	DEG_SPOP_SBC_1	1550:1554	Mutation rewiring degron network	0.0833
p.E1273D	SIDM00839	Colorectal Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.1111
p.E1273D	LoVo	large intestine	COSMIC	PSTPKSE	DEG_SCF_FBW7_2	1259:1265	Mutation rewiring degron network	0.1111
p.I791R	SIDM01343	Gastric Carcinoma	GDSC	VIVTPLVE	DEG_SCF_FBW7_2	790:797	Mutation altering degron motif	0.6991

Kaplan plot for CASP8AP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASP8AP2

UniProt ID: Q9UKL3

Entrez ID: 9994

Protein name: CASP8-associated protein 2 (FLICE-associated huge protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASP8AP2 in