DegronMD

Uniprot ID: Q9UKL3

Source protein: CASP8-associated protein 2

Source gene: CASP8AP2

Class: DEG_SPOP_SBC_1

Location: 895:899

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 88

COIL: 0.9136

CONS_SCORE: 0.3835

DSS_SCORE: 0.5798

HELIX: 0.0682

FCONS_SCORE: 0.6595

RIG_SCORE: 0.6195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q902H	SIDM01293	Colorectal Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	0.25
p.H886L	SIDM01245	T-Lymphoblastic Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.H886L	SIDM00991	T-Lymphoblastic Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	0.0833
p.H886L	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12816	Trophinin	DEG_SPOP_SBC_1	798:802	AHSTS	SPOP	0.7651	More...
Q58WW2	DDB1- and CUL4-associated factor 6	DEG_SPOP_SBC_1	421:425	AHSTS	SPOP	0.5333	More...
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SPOP_SBC_1	404:408	AHSTS	SPOP	0.5117	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	895:899	AHSTS	SPOP	0.9976	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	508:512	AHSTS	SPOP	0.997	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1230:1234	AHSTS	SPOP	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons