DegronMD - Q5JV73(FRMPD3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1154N	TCGA-17-Z060	LUAD	TCGA	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.1944
p.E1143D	TCGA-55-A48Y	LUAD	TCGA	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation altering degron motif	0.5647
p.E1143D	DO26160	LUAD	ICGC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation altering degron motif	0.5647
p.S1243F	TCGA-90-A4ED	LUSC	TCGA	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.S1243F	DO45482	LUSC	ICGC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.E1152K	TCGA-AJ-A3EK	UCEC	TCGA	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.25
p.E1152K	DO41584	UCEC	ICGC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.25
p.E1224D	TCGA-AX-A1CE	UCEC	TCGA	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1667
p.E1224D	DO42280	UCEC	ICGC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1667
p.E944K	TCGA-CN-A6V6	HNSC	TCGA	AATSS	DEG_SPOP_SBC_1	949:953	Mutation rewiring degron network	0.1944
p.E944K	DO218995	HNSC	ICGC	AATSS	DEG_SPOP_SBC_1	949:953	Mutation rewiring degron network	0.1944
p.K1139N	TCGA-D1-A17Q	UCEC	TCGA	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation substituting flanking lysine	0.3611
p.K1139N	DO41903	UCEC	ICGC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation substituting flanking lysine	0.3611
p.E817Q	TCGA-E5-A4TZ	BLCA	TCGA	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.0556
p.E817Q	DO44055	BLCA	ICGC	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.0556
p.S816P	TCGA-EY-A1G8	UCEC	TCGA	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.0833
p.S816P	DO43578	UCEC	ICGC	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.0833
p.A949V	TCGA-G4-6628	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	949:953	Mutation altering degron motif	0.5825
p.A949V	DO10132	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	949:953	Mutation altering degron motif	0.5825
p.A1140V	TCGA-IQ-A61K	HNSC	TCGA	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.2778
p.A1140V	DO228542	GACA	ICGC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.2778
p.A1140V	DO44447	HNSC	ICGC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.2778
p.I790S	TCGA-ND-A4WC	UCS	TCGA	ITPESS	DEG_SCF_FBW7_1	795:800	Mutation rewiring degron network	0.1944
p.S1234C	TCGA-NH-A6GB	COAD	TCGA	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7541
p.S1234C	DO50092	COAD	ICGC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7541
p.A941S	DO50889	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	949:953	Mutation rewiring degron network	0.1111
p.R940K	DO50970	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	949:953	Mutation rewiring degron network	0.0833
p.S955G	DO230449	UTCA	ICGC	AATSS	DEG_SPOP_SBC_1	949:953	Mutation rewiring degron network	0.2778
p.S1242L	SIDM01141	Ovarian Carcinoma	GDSC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1111
p.S1242L	SIDM01649	Non-Cancerous	GDSC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1111
p.S1242L	SIDM00184	Melanoma	GDSC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1111
p.S1242L	ACH-000291	Ovarian Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1111
p.S1242L	ACH-001022	Bone Cancer	CCLE	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1111
p.S1242L	ACH-002355	Non-Cancerous	CCLE	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1111
p.S1149I	SIDM00884	Breast Carcinoma	GDSC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation altering degron motif	0.7341
p.S1149I	ACH-000699	Breast Cancer	CCLE	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation altering degron motif	0.7341
p.S1149I	HCC1395	breast	COSMIC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation altering degron motif	0.7341
p.E1153D	SIDM00441	Acute Myeloid Leukemia	GDSC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.2222
p.E1153D	ACH-002273	Leukemia	CCLE	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.2222
p.E1153D	ML-2	haematopoietic and lymphoid tissue	COSMIC	LESTPKRS	DEG_SCF_FBW7_1	1142:1149	Mutation rewiring degron network	0.2222
p.S1232L	SIDM01177	B-Lymphoblastic Leukemia	GDSC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7667
p.S1232L	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7667
p.D814E	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.1389
p.D814E	ACH-000886	Lung Cancer	CCLE	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.1389
p.D814E	NCI-H2009	lung	COSMIC	DSGHET	DEG_SCF_TRCP1_1	802:807	Mutation rewiring degron network	0.1389
p.N1228S	ACH-000160	Rhabdoid	CCLE	AHSTS	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.2778
p.R948G	ACH-000950	Colon/Colorectal Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	949:953	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMPD3

UniProt ID: Q5JV73

Entrez ID: 84443

Protein name: FERM and PDZ domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMPD3 in