DegronMD

Uniprot ID: Q5JV73

Source protein: FERM and PDZ domain-containing protein 3

Source gene: FRMPD3

Class: DEG_SCF_TRCP1_1

Location: 802:807

E3 ligase: BTRC

DEGRON score: 0.5205

ASA_SCORE: 89.4167

COIL: 0.9132

CONS_SCORE: 0.353

DSS_SCORE: 0.7003

HELIX: 0.0538

FCONS_SCORE: 0.9239

RIG_SCORE: 0.6007

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D814E	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	DSGHET	DEG_SCF_TRCP1_1	0.1389
p.D814E	ACH-000886	Lung Cancer	CCLE	DSGHET	DEG_SCF_TRCP1_1	0.1389
p.D814E	NCI-H2009	lung	COSMIC	DSGHET	DEG_SCF_TRCP1_1	0.1389
p.S816P	TCGA-EY-A1G8	UCEC	TCGA	DSGHET	DEG_SCF_TRCP1_1	0.0833
p.S816P	DO43578	UCEC	ICGC	DSGHET	DEG_SCF_TRCP1_1	0.0833
p.E817Q	TCGA-E5-A4TZ	BLCA	TCGA	DSGHET	DEG_SCF_TRCP1_1	0.0556
p.E817Q	DO44055	BLCA	ICGC	DSGHET	DEG_SCF_TRCP1_1	0.0556

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SCF_TRCP1_1	802:807	DSGHET	BTRC	0.5205	More...
Q8NAX2	Keratinocyte differentiation factor 1	DEG_SCF_TRCP1_1	332:337	DSGHET	BTRC	0.9745	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons